发明授权
- 专利标题： Piperidine derivative
- 专利标题（中）： 哌啶衍生物
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申请号： US12675744申请日： 2008-08-28
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公开(公告)号： US08513422B2公开(公告)日： 2013-08-20
- 发明人: Akio Kakefuda , Kazushi Watanabe , Akio Kamikawa , Kentaro Enjo , Takashi Furutani , Minoru Yasuda
- 申请人： Akio Kakefuda , Kazushi Watanabe , Akio Kamikawa , Kentaro Enjo , Takashi Furutani , Minoru Yasuda
- 申请人地址： JP Tokyo
- 专利权人： Astellas Pharma Inc.
- 当前专利权人： Astellas Pharma Inc.
- 当前专利权人地址： JP Tokyo
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- 优先权： JP2007-225378 20070831
- 国际申请： PCT/JP2008/065429 WO 20080828
- 国际公布： WO2009/028618 WO 20090305
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; C07D211/32
摘要：
As a result of studies on compounds having a selective inhibitory activity against 17βHSD type 5, the present inventors have confirmed that a {1-[(indol-2-yl)carbonyl]piperidyl}alkanol derivative has a potent selective inhibitory activity against 17βHSD type 5. The invention has been completed based on these findings. The compound of the present invention can be used as an agent for treating and/or an agent for preventing diseases associated with 17βHSD type 5, such as benign prostatic hyperplasia and prostate cancer, without accompanying adverse effects due to a decrease in testosterone.
公开/授权文献
- US20100256189A1 PIPERIDINE DERIVATIVE 公开/授权日：2010-10-07
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