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发明授权
US08546394B2 Substituted [1,2,4]triazolo[4,3-A]pyrazine 11-beta-hydroxysteroid dehydrogenase inhibitors 有权
取代的[1,2,4]三唑并[4,3-A]吡嗪11-β-羟基类固醇脱氢酶抑制剂

Substituted [1,2,4]triazolo[4,3-A]pyrazine 11-beta-hydroxysteroid dehydrogenase inhibitors
摘要：
Novel compounds are provided which are 1 1-beta-hydroxysteroid dehydrogenase type I inhibitors. 1 1-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 1 1-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: W-L-Z or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W, L are defined herein and Z is selected from the following bicyclic heteroaryl groups: (a), (b), (c), (d).
摘要（中）：

提供了新的化合物，其为11β-羟基类固醇脱氢酶I型抑制剂。 11β-羟基类固醇脱氢酶I型抑制剂可用于治疗，预防或减缓需要11β-羟基类固醇脱氢酶I型抑制剂治疗的疾病进展。 这些新型化合物具有以下结构：WLZ或其立体异构体或前药或其药学上可接受的盐，其中W，L在本文中定义，Z选自以下双环杂芳基：（a），（b），（c），（d ）。

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