- 专利标题: Antibody targeting osteoclast-related protein Siglec-15
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申请号: US12677621申请日: 2008-10-08
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公开(公告)号: US08546540B2公开(公告)日: 2013-10-01
- 发明人: Yoshiharu Hiruma , Eisuke Tsuda
- 申请人: Yoshiharu Hiruma , Eisuke Tsuda
- 申请人地址: JP Tokyo
- 专利权人: Daiichi Sankyo Company, Limited
- 当前专利权人: Daiichi Sankyo Company, Limited
- 当前专利权人地址: JP Tokyo
- 代理机构: Foley & Lardner LLP
- 优先权: JP2007-265420 20071011
- 国际申请: PCT/JP2008/068287 WO 20081008
- 国际公布: WO2009/048072 WO 20090416
- 主分类号: C07K16/00
- IPC分类号: C07K16/00 ; C07K16/46 ; C07K16/28 ; C12N5/20
摘要:
To provide a method of detecting abnormal bone metabolism by using a gene strongly expressed in an osteoclast; a method of screening a compound having a therapeutic and/or preventive effect on abnormal bone metabolism; and a pharmaceutical composition for treating and/or preventing abnormal bone metabolism. Provision of a method of detecting abnormal bone metabolism by using the expression of human Siglec-15 gene as an index; a pharmaceutical composition containing an antibody which specifically recognizes human Siglec-15 and has an activity of inhibiting osteoclast formation; and the like.
公开/授权文献
- US20100209428A1 ANTIBODY TARGETING OSTEOCLAST-RELATED PROTEIN Siglec-15 公开/授权日:2010-08-19