- 专利标题： Benzodioxane inhibitors of leukotriene production
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申请号： US13418377申请日： 2012-03-13
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公开(公告)号： US08551982B2公开(公告)日： 2013-10-08
- 发明人: Asitha Abeywardane , Michael J. Burke , Thomas Martin Kirrane , Matthew Russell Netherton , Anil Kumar Padyana , Lana Louise Smith Keenan , Hidenori Takahashi , Michael Robert Turner , Qiang Zhang , Qing Zhang
- 申请人： Asitha Abeywardane , Michael J. Burke , Thomas Martin Kirrane , Matthew Russell Netherton , Anil Kumar Padyana , Lana Louise Smith Keenan , Hidenori Takahashi , Michael Robert Turner , Qiang Zhang , Qing Zhang
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： DE Ingelheim am Rhein
- 代理商 Michael P. Morris; David L. Kershner
- 主分类号： A61K31/553
- IPC分类号： A61K31/553 ; A61K31/55 ; A61K31/551 ; A61K31/438 ; A61K31/436 ; A61K31/453 ; A61K31/5377 ; A61K31/40 ; A61K31/4025 ; A61K31/357 ; C07D267/08 ; C07D225/02 ; C07D243/08 ; C07D245/02 ; C07D221/20 ; C07D491/04 ; C07D401/02 ; C07D413/14 ; C07D405/14 ; C07D405/02 ; C07D319/16
摘要：
The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
公开/授权文献
- US20130196973A1 BENZODIOXANE INHIBITORS OF LEUKOTRIENE PRODUCTION 公开/授权日：2013-08-01
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