发明授权
- 专利标题： Triazole derivatives for treatment of Alzheimer's disease
- 专利标题（中）： 用于治疗阿尔茨海默病的三唑衍生物
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申请号： US13139830申请日： 2009-12-07
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公开(公告)号： US08575150B2公开(公告)日： 2013-11-05
- 发明人: Christian Fischer , Joey Methot , Hua Zhou , Adam J. Schell , Benito Munoz , Alexey A. Rivkin , Sean P. Ahearn , Stephanie Chichetti , Rachel N. MacCoss , Sam Kattar , Matthew Christopher , Chaomin Li , Andrew Rosenau , William Colby Brown
- 申请人： Christian Fischer , Joey Methot , Hua Zhou , Adam J. Schell , Benito Munoz , Alexey A. Rivkin , Sean P. Ahearn , Stephanie Chichetti , Rachel N. MacCoss , Sam Kattar , Matthew Christopher , Chaomin Li , Andrew Rosenau , William Colby Brown
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Susan L. Hess; John C. Todaro
- 国际申请： PCT/US2009/066914 WO 20091207
- 国际公布： WO2010/071741 WO 20100624
- 主分类号： C07D249/14
- IPC分类号： C07D249/14 ; A61K31/4196
摘要：
According to the invention there is provided a compound of formula I or a pharmaceutically acceptable salt or hydrate thereof; wherein the variables are as defined herein. The compounds selectively attenuate the production of Aβ42 and hence are useful in treatment of Alzheimer's disease and related conditions.
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