Invention Grant
- Patent Title: Processes
- Patent Title (中): 过程
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Application No.: US12863213Application Date: 2009-01-16
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Publication No.: US08580974B2Publication Date: 2013-11-12
- Inventor: David Hook , Bernhard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
- Applicant: David Hook , Bernhard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Joseph Majka; Matthew Mulkeen
- Priority: EP08150353 20080117
- International Application: PCT/EP2009/050510 WO 20090116
- International Announcement: WO2009/090251 WO 20090723
- Main IPC: C07D207/38
- IPC: C07D207/38 ; C07D207/26

Abstract:
The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
Public/Granted literature
- US20110046397A1 NEW PROCESSES Public/Granted day:2011-02-24
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