Invention Grant
US08586291B2 Mutations in the Bcr-Abl tyrosine kinase associated with resistance to ST1-571
有权
与ST1-571抗性相关的Bcr-Abl酪氨酸激酶突变
- Patent Title: Mutations in the Bcr-Abl tyrosine kinase associated with resistance to ST1-571
- Patent Title (中): 与ST1-571抗性相关的Bcr-Abl酪氨酸激酶突变
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Application No.: US12381448Application Date: 2009-03-11
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Publication No.: US08586291B2Publication Date: 2013-11-19
- Inventor: Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll
- Applicant: Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Kenyon & Kenyon LLP
- Main IPC: C12Q1/00
- IPC: C12Q1/00 ; G01N33/574
Abstract:
The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
Public/Granted literature
- US20100055687A1 Mutations in the BCR-ABL tyrosine kinase associated with resistance to ST1-571 Public/Granted day:2010-03-04
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