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公开(公告)号：US09085644B2
公开(公告)日：2015-07-21
申请号：US13547954
申请日：2012-07-12
CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52
摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
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公开(公告)号：US20150065546A1
公开(公告)日：2015-03-05
申请号：US14224005
申请日：2014-03-24
申请人： Michael E. Jung , Dongwon Yoo , Charles L. Sawyers , Chris Tran , John Wongvipat
发明人： Michael E. Jung , Dongwon Yoo , Charles L. Sawyers , Chris Tran , John Wongvipat
IPC分类号： C07D403/10 , C07D235/02 , C07D233/86
CPC分类号： C07D403/10 , A61K31/4166 , A61K31/4178 , A61K31/4184 , C07D233/86 , C07D235/02
摘要： The present invention relates to diarylhydantoin compounds and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
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3.发明授权Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571 有权与STI-571抗性相关的Bcr-Abl酪氨酸激酶突变公开(公告)号：US08697348B2
公开(公告)日：2014-04-15
申请号：US11485023
申请日：2006-07-12
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53 , G01N33/574 , G01N33/00
CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52
摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
摘要翻译： 本文描述的本发明涉及新型基因及其编码的蛋白质，称为与STI-571（例如，T315I Bcr-Abl）抗性相关的突变体，以及可用于管理表达MARS的各种癌症的诊断和治疗方法和组合物。 本发明还提供用于鉴定结合和/或调节MARS的功能活性的分子的方法。
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4.发明申请ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES 有权用于治疗前列腺癌和雄激素受体相关疾病的雄激素受体调节剂公开(公告)号：US20110003839A1
公开(公告)日：2011-01-06
申请号：US12294881
申请日：2007-03-27
申请人： Michael E. Jung , Charles L. Sawyers , Samedy Ouk , Chris Tran , John Wongvipat
发明人： Michael E. Jung , Charles L. Sawyers , Samedy Ouk , Chris Tran , John Wongvipat
IPC分类号： A61K31/4439 , C07D401/04 , A61P35/00
CPC分类号： A61K31/4439 , A61K9/48 , C07D401/04
摘要： A hydantoin compound useful for the prevention or treatment of hyperproliferative diseases or disorders.
摘要翻译： 可用于预防或治疗过度增殖性疾病或障碍的乙内酰脲化合物。
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公开(公告)号：US20100210665A1
公开(公告)日：2010-08-19
申请号：US12708531
申请日：2010-02-18
申请人： Charles L. Sawyers , Michael E. Jung , Charlie D. Chen , Samedy Ouk , Derek Welsbie , Chris Tran , John Wongvipat
发明人： Charles L. Sawyers , Michael E. Jung , Charlie D. Chen , Samedy Ouk , Derek Welsbie , Chris Tran , John Wongvipat
IPC分类号： A61K31/497 , C07D233/86 , A61K31/4166 , C07D401/04 , A61K31/4439 , C07D233/84 , C07D233/76 , C07D471/10 , A61K31/438 , C07D233/88 , A61K31/4164 , C07D241/04 , A61P35/00
CPC分类号： C07D235/02 , C07D233/70 , C07D233/74 , C07D233/86 , C07D471/10
摘要： The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
摘要翻译： 本发明涉及二芳基乙内酰脲化合物，包括二芳基硫代乙内酰脲及其合成方法，并用于治疗激素难治性前列腺癌。
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6.发明申请Methods and Materials for Examining the P13k/Akt Pathway in Gliomas and Prostate Cancers 审中-公开检查胶质瘤和前列腺癌P13k / Akt途径的方法和材料公开(公告)号：US20080299589A1
公开(公告)日：2008-12-04
申请号：US11667430
申请日：2004-11-08
IPC分类号： G01N33/574 , C12Q1/02
CPC分类号： G01N33/57484 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57426 , G01N33/5743 , G01N33/57434 , G01N33/57438 , G01N33/57442 , G01N33/57449 , G01N33/57492 , G01N33/57496
摘要： The invention disclosed herein provides methods for the examination and/or quantification of the PI3K/Akt and Ras/MAPK biochemical pathways that are disregulated in pathologies such as cancers of the prostate and gliomas. The invention disclosed herein further provides reagents and kits adapted for performing such methods.
摘要翻译： 本文公开的本发明提供了用于检查和/或定量PI3K / Akt和Ras / MAPK生物化学途径的方法，所述途径在诸如前列腺癌和神经胶质瘤的病理学中被调节。 本文公开的本发明进一步提供适于执行这些方法的试剂和试剂盒。
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公开(公告)号：US06815574B2
公开(公告)日：2004-11-09
申请号：US10062684
申请日：2002-01-30
IPC分类号： A01K6700
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K49/0008
摘要： The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
摘要翻译： 本发明提供了具有局部晚期或转移性前列腺癌的人前列腺异种移植物的免疫缺陷小鼠及其用途。
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8.发明授权Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases 有权雄激素受体调节剂用于治疗前列腺癌和雄激素受体相关疾病公开(公告)号：US08802689B2
公开(公告)日：2014-08-12
申请号：US13615085
申请日：2012-09-13
申请人： Michael E. Jung , Charles L. Sawyers , Samedy Ouk , Chris Tran , John Wongvipat
发明人： Michael E. Jung , Charles L. Sawyers , Samedy Ouk , Chris Tran , John Wongvipat
IPC分类号： A61K31/44
CPC分类号： A61K31/4439 , A61K9/48 , C07D401/04
摘要： Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.
摘要翻译： 本文所描述的是可用于预防或治疗过度增殖性疾病或病症的化合物。
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公开(公告)号：US08648105B2
公开(公告)日：2014-02-11
申请号：US13333543
申请日：2011-12-21
申请人： Michael E. Jung , Dongwon Yoo , Charles L. Sawyers , Chris Tran , John Wongvipat
发明人： Michael E. Jung , Dongwon Yoo , Charles L. Sawyers , Chris Tran , John Wongvipat
IPC分类号： A61K31/4166 , C07D233/86
CPC分类号： C07D235/02 , A61K31/4166 , A61K31/4184 , C07D233/86
摘要： The present invention relates to diarylthiohydantoin compounds and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
摘要翻译： 本发明涉及二芳基硫代乙内酰脲化合物及其合成方法，并用于治疗激素难治性前列腺癌。
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公开(公告)号：US20130034501A1
公开(公告)日：2013-02-07
申请号：US13619280
申请日：2012-09-14
申请人： Charles L. Sawyers , Michael E. Jung , Charlie D. Chen , Samedy Ouk , Derek Welsbie , Chris Tran , John Wongvipat , Dongwon Yoo
发明人： Charles L. Sawyers , Michael E. Jung , Charlie D. Chen , Samedy Ouk , Derek Welsbie , Chris Tran , John Wongvipat , Dongwon Yoo
IPC分类号： C07D233/02 , C07D235/02 , A61P35/00 , A61K31/496 , C12Q1/02 , A61K49/00 , A61K31/4166 , C07D403/10
CPC分类号： C07D235/02 , C07D233/70 , C07D233/74 , C07D233/86 , C07D471/10
摘要： The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone lefiactory prostate cancer.
摘要翻译： 本发明涉及二芳基乙内酰脲化合物，包括二芳基硫代乙内酰脲及其合成方法，并用于治疗激素性左前列腺癌。
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