发明授权
US08586364B2 Cells and methodology to generate non-segmented negative-strand RNA viruses
有权
产生非分段负链RNA病毒的细胞和方法
- 专利标题： Cells and methodology to generate non-segmented negative-strand RNA viruses
- 专利标题（中）： 产生非分段负链RNA病毒的细胞和方法
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申请号： US12448468申请日： 2007-12-21
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公开(公告)号： US08586364B2公开(公告)日： 2013-11-19
- 发明人: Frédéric Tangy , Pierre Charneau , Yves Jacob
- 申请人： Frédéric Tangy , Pierre Charneau , Yves Jacob
- 申请人地址： FR Paris
- 专利权人： Institut Pasteur
- 当前专利权人： Institut Pasteur
- 当前专利权人地址： FR Paris
- 代理机构： Law Office of Salvatore Arrigo and Scott Lee, LLP
- 优先权： EP06292025 20061222
- 国际申请： PCT/IB2007/004444 WO 20071221
- 国际公布： WO2008/078198 WO 20080703
- 主分类号： C12N7/01
- IPC分类号： C12N7/01 ; C12N7/02 ; C12N7/04 ; A61K39/165
摘要：
The present invention relates to recombinant cells as well as to methods for the generation of non-segmented negative-sense single-stranded RNA viruses (NNV or mononegavirales) from cloned deoxyribonucleic acid (cDNA), especially from measles virus and in particular from attenuated strains such as those approved for vaccination, in particular from the attenuated Schwarz measles virus and various recombinant Schwarz measles-based viruses expressing heterologous sequences. Such rescued viruses can be used, after amplification, as vaccines for immunization against measles and/or against the heterologous peptides or proteins expressed.
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