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1.发明授权公开(公告)号：US08586364B2
公开(公告)日：2013-11-19
申请号：US12448468
申请日：2007-12-21
申请人： Frédéric Tangy , Pierre Charneau , Yves Jacob
发明人： Frédéric Tangy , Pierre Charneau , Yves Jacob
IPC分类号： C12N7/01 , C12N7/02 , C12N7/04 , A61K39/165
CPC分类号： C12N7/00 , C07K14/005 , C12N15/86 , C12N2740/16021 , C12N2740/16043 , C12N2740/16052 , C12N2760/18022 , C12N2760/18422 , C12N2830/48
摘要： The present invention relates to recombinant cells as well as to methods for the generation of non-segmented negative-sense single-stranded RNA viruses (NNV or mononegavirales) from cloned deoxyribonucleic acid (cDNA), especially from measles virus and in particular from attenuated strains such as those approved for vaccination, in particular from the attenuated Schwarz measles virus and various recombinant Schwarz measles-based viruses expressing heterologous sequences. Such rescued viruses can be used, after amplification, as vaccines for immunization against measles and/or against the heterologous peptides or proteins expressed.
摘要翻译： 本发明涉及重组细胞，以及用于从克隆的脱氧核糖核酸（cDNA），特别是麻疹病毒，特别是从减毒菌株中产生非分段的负义单链RNA病毒（NNV或单酮巴西）的方法 例如批准用于疫苗接种的那些，特别是来自减毒的施瓦氏麻疹病毒和表达异源序列的各种重组Schwarz麻疹病毒。 这样的拯救病毒可以在扩增后用作针对麻疹免疫的疫苗和/或针对所表达的异源肽或蛋白质。
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2.发明申请公开(公告)号：US20100144040A1
公开(公告)日：2010-06-10
申请号：US12448468
申请日：2007-12-21
申请人： Frédéric Tangy , Pierre Charneau , Yves Jacob
发明人： Frédéric Tangy , Pierre Charneau , Yves Jacob
CPC分类号： C12N7/00 , C07K14/005 , C12N15/86 , C12N2740/16021 , C12N2740/16043 , C12N2740/16052 , C12N2760/18022 , C12N2760/18422 , C12N2830/48
摘要： The present invention relates to recombinant cells as well as to methods for the generation of non-segmented negative-sense single-stranded RNA viruses (NNV or mononegavirales) from cloned deoxyribonucleic acid (cDNA), especially from measles virus and in particular from attenuated strains such as those approved for vaccination, in particular from the attenuated Schwarz measles virus and various recombinant Schwarz measles-based viruses expressing heterologous sequences. Such rescued viruses can be used, after amplification, as vaccines for immunization against measles and/or against the heterologous peptides or proteins expressed.
摘要翻译： 本发明涉及重组细胞，以及用于从克隆的脱氧核糖核酸（cDNA），特别是麻疹病毒，特别是从减毒菌株中产生非分段的负义单链RNA病毒（NNV或单酮巴西）的方法 例如批准用于疫苗接种的那些，特别是来自减毒的施瓦氏麻疹病毒和表达异源序列的各种重组Schwarz麻疹病毒。 这样的拯救病毒可以在扩增后用作针对麻疹免疫的疫苗和/或针对所表达的异源肽或蛋白质。
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3.发明申请公开(公告)号：US20110065089A1
公开(公告)日：2011-03-17
申请号：US12754908
申请日：2010-04-06
申请人： Sylvie Van Der Werf , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederik Kunst , Benoît Callendret , Jean-Michel Betton , Valérie Lorin , Sylvie Gerbaud , Ana Maria Burguiere , Saliha Azebi , Pierre Charneau , Frédéric Tangy , Chantal Combredet , Jean-François Delagneau , Monique Martin
发明人： Sylvie Van Der Werf , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederik Kunst , Benoît Callendret , Jean-Michel Betton , Valérie Lorin , Sylvie Gerbaud , Ana Maria Burguiere , Saliha Azebi , Pierre Charneau , Frédéric Tangy , Chantal Combredet , Jean-François Delagneau , Monique Martin
CPC分类号： C07K14/005 , C12N7/00 , C12N2770/20022 , G01N33/569
摘要： The invention relates to a novel strain of severe acute respiratory syndrome (SARS)-associated coronavirus, resulting from a sample collected in Hanoi (Vietnam), reference number 031589, nucleic acid molecules originating from the genome of same, proteins and peptides coded by said nucleic acid molecules and, more specifically, protein N and the applications thereof, for example, as diagnostic reagents and/or as a vaccine.
摘要翻译： 本发明涉及由河内（越南）收集的样品，参考号031589，源自其基因组的核酸分子产生的重症急性呼吸综合征（SARS）相关冠状病毒的新型菌株，由所述 核酸分子，更具体地，蛋白N及其应用，例如作为诊断试剂和/或疫苗。
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公开(公告)号：US07736850B2
公开(公告)日：2010-06-15
申请号：US10581356
申请日：2004-12-02
申请人： Sylvie Van Der Werf , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederick Kunst , Benoît Callendret , Jean-Michel Betton , Valérie Lorin , Sylvie Gerbaud , Ana Maria Burguiere , Saliha Azebi , Pierre Charneau , Frédéric Tangy , Chantal Combredet , Jean-François Delagneau , Monique Martin
发明人： Sylvie Van Der Werf , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederick Kunst , Benoît Callendret , Jean-Michel Betton , Valérie Lorin , Sylvie Gerbaud , Ana Maria Burguiere , Saliha Azebi , Pierre Charneau , Frédéric Tangy , Chantal Combredet , Jean-François Delagneau , Monique Martin
IPC分类号： C12Q1/68
CPC分类号： C07K14/005 , C12N7/00 , C12N2770/20022 , G01N33/569
摘要： The invention relates to a novel strain of severe acute respiratory syndrome (SARS)-associated coronavirus, resulting from a sample collected in Hanoi (Vietnam), reference number 031589, nucleic acid molecules originating from the genome of same, proteins and peptides coded by said nucleic acid molecules and, more specifically, protein N and the applications thereof, for example, as diagnostic reagents and/or as a vaccine.
摘要翻译： 本发明涉及由河内（越南）收集的样品，参考号031589，源自其基因组的核酸分子产生的重症急性呼吸综合征（SARS）相关冠状病毒的新型菌株，由所述 核酸分子，更具体地，蛋白N及其应用，例如作为诊断试剂和/或疫苗。
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5.发明授权Recombinant lentiviral vector for expression of a flaviviridae protein and applications thereof as a vaccine 有权用于表达黄病毒科蛋白的重组慢病毒载体及其作为疫苗的应用公开(公告)号：US08716013B2
公开(公告)日：2014-05-06
申请号：US12929215
申请日：2011-01-07
CPC分类号： C12N15/86 , A61K2039/53 , C07K14/005 , C12N2740/16043 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/394
摘要： Use of a recombinant lentiviral vector comprising a polynucleotide fragment encoding at least one protein of a virus of the family Flaviviridae or an immunogenic peptide of at least 8 amino acids of said protein, for preparing a pharmaceutical composition intended for the prevention and/or the treatment of a Flaviviridae infection in a sensitive species.
摘要翻译： 使用重组慢病毒载体，其包含编码至少一种黄病毒科病毒蛋白的多核苷酸片段或所述蛋白质的至少8个氨基酸的免疫原性肽，用于制备用于预防和/或治疗的药物组合物 的敏感物种中的黄病毒科感染。
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公开(公告)号：US08343718B2
公开(公告)日：2013-01-01
申请号：US12754908
申请日：2010-04-06
申请人： Sylvie Van Der Werf , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederik Kunst , Benoît Callendret , Jean-Michel Betton , Valérie Lorin , Sylvie Gerbaud , Ana Maria Burguiere , Saliha Azebi , Pierre Charneau , Frédéric Tangy , Chantal Combredet , Jean-François Delagneau , Monique Martin
发明人： Sylvie Van Der Werf , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederik Kunst , Benoît Callendret , Jean-Michel Betton , Valérie Lorin , Sylvie Gerbaud , Ana Maria Burguiere , Saliha Azebi , Pierre Charneau , Frédéric Tangy , Chantal Combredet , Jean-François Delagneau , Monique Martin
IPC分类号： C12Q1/70 , G01N33/53 , G01N33/542 , G01N33/00
CPC分类号： C07K14/005 , C12N7/00 , C12N2770/20022 , G01N33/569
摘要： The invention relates to a novel strain of severe acute respiratory syndrome (SARS)-associated coronavirus, resulting from a sample collected in Hanoi (Vietnam), reference number 031589, nucleic acid molecules originating from the genome of same, proteins and peptides coded by said nucleic acid molecules and, more specifically, protein N and the applications thereof, for example, as diagnostic reagents and/or as a vaccine.
摘要翻译： 本发明涉及由河内（越南）收集的样品，参考号031589，源自其基因组的核酸分子产生的重症急性呼吸综合征（SARS）相关冠状病毒的新型菌株，由所述 核酸分子，更具体地，蛋白N及其应用，例如作为诊断试剂和/或疫苗。
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7.发明申请USE OF PROTEINS AND PEPTIDES ENCODED BY THE GENOME OF A NOVEL SARS-ASSOCIATED CORONAVIRUS STRAIN 审中-公开使用由新型SARS相关的金黄色葡萄球菌菌株编码的蛋白质和肽公开(公告)号：US20120082693A1
公开(公告)日：2012-04-05
申请号：US13187011
申请日：2011-07-20
申请人： Sylvie VAN DER WERF , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederik Kunst , Benoît Callendret , Jean-Michel Betton , Valérie Lorin , Sylvie Gerbaud , Ana Maria Burguiere , Saliha Azebi , Pierre Charneau , Frédéric Tangy , Chantal Combredet , Jean-François Delagneau , Monique Martin
发明人： Sylvie VAN DER WERF , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederik Kunst , Benoît Callendret , Jean-Michel Betton , Valérie Lorin , Sylvie Gerbaud , Ana Maria Burguiere , Saliha Azebi , Pierre Charneau , Frédéric Tangy , Chantal Combredet , Jean-François Delagneau , Monique Martin
IPC分类号： A61K39/215 , C12N15/50 , C12N15/63 , C12N1/21 , C12N7/01 , A61P31/14 , C12N5/10 , C07K16/10 , C12Q1/70 , C07K19/00 , A61P37/04 , C07K14/165 , C12P21/02
CPC分类号： C07K14/005 , C12N7/00 , C12N2770/20022 , G01N33/569
摘要： The invention relates to the use of proteins and peptides coded by the genome of the isolated or purified strain of severe acute respiratory syndrome (SARS)-associated coronavirus, resulting from sample reference number 031589 and, in particular, to the use of protein S and the derivative antibodies thereof as diagnostic reagents and as a vaccine.
摘要翻译： 本发明涉及由分离或纯化的重症急性呼吸综合征（SARS）相关冠状病毒株的基因组编码的蛋白质和肽的用途，由样品参考号031589得到，特别是使用蛋白S和 其衍生抗体作为诊断试剂和疫苗。
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8.发明申请Recombinant lentiviral vector for expression of a flaviviridae protein and applications thereof as a vaccine 有权用于表达黄病毒科蛋白的重组慢病毒载体及其作为疫苗的应用公开(公告)号：US20110206710A1
公开(公告)日：2011-08-25
申请号：US12929215
申请日：2011-01-07
CPC分类号： C12N15/86 , A61K2039/53 , C07K14/005 , C12N2740/16043 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/394
摘要： Use of a recombinant lentiviral vector comprising a polynucleotide fragment encoding at least one protein of a virus of the family Flaviviridae or an immunogenic peptide of at least 8 amino acids of said protein, for preparing a pharmaceutical composition intended for the prevention and/or the treatment of a Flaviviridae infection in a sensitive species.
摘要翻译： 使用重组慢病毒载体，其包含编码至少一种黄病毒科病毒蛋白的多核苷酸片段或所述蛋白质的至少8个氨基酸的免疫原性肽，用于制备用于预防和/或治疗的药物组合物 的敏感物种中的黄病毒科感染。
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公开(公告)号：US08980634B2
公开(公告)日：2015-03-17
申请号：US12865567
申请日：2009-01-30
申请人： Chaouki Miled , Frédéric Tangy , Yves Jacob
发明人： Chaouki Miled , Frédéric Tangy , Yves Jacob
IPC分类号： A61K39/12 , C07K14/08 , A61P37/02 , C12N15/63 , C12Q1/02 , C12N1/19 , C12P21/00 , C12N7/00 , A61K39/165 , C12N15/81 , A61K39/00
CPC分类号： A61K39/165 , A61K39/12 , A61K2039/525 , A61K2039/5252 , A61K2039/5258 , C07K14/005 , C12N7/00 , C12N15/81 , C12N2760/00051 , C12N2760/18434 , C12N2760/18451 , C12N2770/24134
摘要： The present invention relates to a methodology for the generation of infectious ribonucleoparticles (RNPs) of negative-strand RNA viruses, and in particular of non-segmented negative-strand RNA viruses in yeast, especially in budding yeast. Accordingly, the patent application relates to a recombinant yeast strain suitable for the rescue of infectious non-segmented negative-strand RNA virus particles or infectious virus-like particles. The invention also relates to the use of the recombinant yeast to prepare vaccine seed and to the use of the produced RNPs or RNPs-like to prepare vaccine formulations. It also concerns the use of the recombinant yeast for the screening of libraries of DNA.
摘要翻译： 本发明涉及用于产生负链RNA病毒的感染性核糖核酸微粒（RNP）的方法，特别涉及酵母中特别是非分段负链RNA病毒的方法，特别是在芽殖酵母中。 因此，该专利申请涉及适用于拯救感染性非分段负链RNA病毒颗粒或感染性病毒样颗粒的重组酵母菌株。 本发明还涉及重组酵母制备疫苗种子的用途，以及使用所产生的RNP或类似RNP来制备疫苗制剂。 它还涉及使用重组酵母筛选DNA文库。
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公开(公告)号：US20110311581A1
公开(公告)日：2011-12-22
申请号：US12865567
申请日：2009-01-30
申请人： Chaouki Miled , Frédéric Tangy , Yves Jacob
发明人： Chaouki Miled , Frédéric Tangy , Yves Jacob
CPC分类号： A61K39/165 , A61K39/12 , A61K2039/525 , A61K2039/5252 , A61K2039/5258 , C07K14/005 , C12N7/00 , C12N15/81 , C12N2760/00051 , C12N2760/18434 , C12N2760/18451 , C12N2770/24134
摘要： The present invention relates to a methodology for the generation of infectious ribonucleoparticles (RNPs) of negative-strand RNA viruses, and in particular of non-segmented negative-strand RNA viruses in yeast, especially in budding yeast. Accordingly, the patent application relates to a recombinant yeast strain suitable for the rescue of infectious non-segmented negative-strand RNA virus particles or infectious virus-like particles. The invention also relates to the use of the recombinant yeast to prepare vaccine seed and to the use of the produced RNPs or RNPs-like to prepare vaccine formulations. It also concerns the use of the recombinant yeast for the screening of libraries of DNA.
摘要翻译： 本发明涉及用于产生负链RNA病毒的感染性核糖核酸微粒（RNP）的方法，特别涉及酵母中特别是非分段负链RNA病毒的方法，特别是在芽殖酵母中。 因此，该专利申请涉及适用于拯救感染性非分段负链RNA病毒颗粒或感染性病毒样颗粒的重组酵母菌株。 本发明还涉及重组酵母制备疫苗种子的用途，以及使用所产生的RNP或类似RNP来制备疫苗制剂。 它还涉及使用重组酵母筛选DNA文库。
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