发明授权
- 专利标题： Humanized anti-human α9-integrin antibody
- 专利标题（中）： 人源化抗人α9整联蛋白抗体
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申请号： US12812341申请日： 2009-01-09
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公开(公告)号： US08603476B2公开(公告)日： 2013-12-10
- 发明人: Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
- 申请人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
- 申请人地址： JP Tokyo
- 专利权人： Astellas Pharma Inc.
- 当前专利权人： Astellas Pharma Inc.
- 当前专利权人地址： JP Tokyo
- 代理机构： Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 优先权： JP2008-004975 20080111; JP2008-282496 20081031
- 国际申请： PCT/JP2009/050187 WO 20090109
- 国际公布： WO2009/088064 WO 20090716
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.
公开/授权文献
- US20110059077A1 HUMANIZED ANTI-HUMAN ALPHA 9-INTEGRIN ANTIBODY 公开/授权日：2011-03-10