发明授权
- 专利标题： Soft capsule of butylphthalide and a process for preparing the same
- 专利标题（中）： 丁基苯酞的软胶囊及其制备方法
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申请号： US13092610申请日： 2011-04-22
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公开(公告)号： US08609137B2公开(公告)日： 2013-12-17
- 发明人: Jianqing Li , Min Bai , Wenmin Guo , Surui Chen , Liyun Liu , Guirong Zhou
- 申请人： Jianqing Li , Min Bai , Wenmin Guo , Surui Chen , Liyun Liu , Guirong Zhou
- 申请人地址： CN Hebei CN Hebei
- 专利权人： CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.,CSPC NBP Pharmaceutical Co., Ltd.
- 当前专利权人： CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.,CSPC NBP Pharmaceutical Co., Ltd.
- 当前专利权人地址： CN Hebei CN Hebei
- 代理机构： Edwards Wildman Palmer LLP
- 代理商 Ralph A. Loren, Esq.; Richard B. Emmons
- 优先权： CN200310119336 20031205
- 主分类号： A61K9/48
- IPC分类号： A61K9/48
摘要：
The present invention discloses a novel soft capsule of butylphthalide and a process for preparing the same. The soft capsule of butylphthalide is composed of a capsule wall material and a drug-containing oil, wherein the drug-containing oil is essentially composed of butylphthalide and a vegetable oil as the diluent in a weight ratio of about 1:0˜10. The capsule wall material is composed of a capsule wall matrix, a plasticizer and water in a weight ratio of 1:0.2˜0.4:0.8˜1.3. The soft capsule of butylphthalide described in the present invention can mask the strong and special flavor of butylphthalide, and overcome the difficulties associated with formulating oily active ingredient into other oral formulation. The disintegration time of the soft capsule satisfies the requirement of Pharmacopoeia of P.R. China.
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