公开(公告)号：US20120052117A1

公开(公告)日：2012-03-01

申请号：US13092610

申请日：2011-04-22

申请人： Jianqing Li ,  Min Bai ,  Wenmin Guo ,  Surui Chen ,  Liyun Liu ,  Guirong Zhou

发明人： Jianqing Li ,  Min Bai ,  Wenmin Guo ,  Surui Chen ,  Liyun Liu ,  Guirong Zhou

IPC分类号： A61K9/48 ,  A61K31/05

CPC分类号： A61K9/4825 ,  A61K9/4816 ,  A61K9/4875 ,  A61K31/34 ,  A61K31/365

摘要： The present invention discloses a novel soft capsule of butylphthalide and a process for preparing the same. The soft capsule of butylphthalide is composed of a capsule wall material and a drug-containing oil, wherein the drug-containing oil is essentially composed of butylphthalide and a vegetable oil as the diluent in a weight ratio of about 1:0˜10. The capsule wall material is composed of a capsule wall matrix, a plasticizer and water in a weight ratio of 1:0.2˜0.4:0.8˜1.3. The soft capsule of butylphthalide described in the present invention can mask the strong and special flavour of butylphthalide, and overcome the difficulties associated with formulating oily active ingredient into other oral formulation. The disintegration time of the soft capsule satisfies the requirement of Pharmacopoeia of P.R. China.

摘要翻译： 本发明公开了一种丁基苯酞的新型软胶囊及其制备方法。 丁基苯酞的软胶囊由胶囊壁材料和药物含油组成，其中含药油基本上由丁基苯酞和植物油作为稀释剂组成，重量比为约1:0〜10。 胶囊壁材料由胶囊壁基质，增塑剂和水组成，重量比为1:0.2〜0.4：0.8〜1.3。 本发明中描述的丁基苯酞的软胶囊可以掩蔽丁苯酞的强烈和特殊风味，并克服与将油性活性成分配制成其它口服制剂相关的困难。 软胶囊的分解时间满足中国药典的药典要求。

公开(公告)号：USD1043144S1

公开(公告)日：2024-09-24

申请号：US29884163

申请日：2023-02-08

申请人： Liyun Liu

设计人： Liyun Liu

摘要： FIG. 1 is a top perspective view of a shoe stool, showing my new design;
FIG. 2 is a bottom perspective view thereof;
FIG. 3 is a front elevational view thereof, the rear elevational view is identical;
FIG. 4 is a left side view thereof, the right side view is identical;
FIG. 5 is a top plan view thereof; and,
FIG. 6 is a bottom plan view thereof.

公开(公告)号：US08609137B2

公开(公告)日：2013-12-17

申请号：US13092610

申请日：2011-04-22

申请人： Jianqing Li ,  Min Bai ,  Wenmin Guo ,  Surui Chen ,  Liyun Liu ,  Guirong Zhou

发明人： Jianqing Li ,  Min Bai ,  Wenmin Guo ,  Surui Chen ,  Liyun Liu ,  Guirong Zhou

IPC分类号： A61K9/48

CPC分类号： A61K9/4825 ,  A61K9/4816 ,  A61K9/4875 ,  A61K31/34 ,  A61K31/365

摘要： The present invention discloses a novel soft capsule of butylphthalide and a process for preparing the same. The soft capsule of butylphthalide is composed of a capsule wall material and a drug-containing oil, wherein the drug-containing oil is essentially composed of butylphthalide and a vegetable oil as the diluent in a weight ratio of about 1:0˜10. The capsule wall material is composed of a capsule wall matrix, a plasticizer and water in a weight ratio of 1:0.2˜0.4:0.8˜1.3. The soft capsule of butylphthalide described in the present invention can mask the strong and special flavor of butylphthalide, and overcome the difficulties associated with formulating oily active ingredient into other oral formulation. The disintegration time of the soft capsule satisfies the requirement of Pharmacopoeia of P.R. China.

摘要翻译： 本发明公开了一种丁基苯酞的新型软胶囊及其制备方法。 丁基苯酞的软胶囊由胶囊壁材料和药物含油组成，其中药物含油基本上由丁基苯酞和作为稀释剂的植物油组成，重量比为约1:0〜10。 胶囊壁材料由胶囊壁基质，增塑剂和水组成，重量比为1:0.2〜0.4:0.8〜1.3。 本发明中描述的丁基苯酞的软胶囊可以掩蔽丁苯酞的强烈和特殊风味，并克服与将油性活性成分配制成其它口服制剂相关的困难。 软胶囊的分解时间满足中国药典的药典要求。

公开(公告)号：US20080020034A1

公开(公告)日：2008-01-24

申请号：US10581370

申请日：2004-12-03

申请人： Jianqing Li ,  Min Bai ,  Wenmin Guo ,  Surui Chen ,  Liyun Liu ,  Guirong Zhou

发明人： Jianqing Li ,  Min Bai ,  Wenmin Guo ,  Surui Chen ,  Liyun Liu ,  Guirong Zhou

IPC分类号： A61K9/48 ,  A61K31/34

CPC分类号： A61K9/4825 ,  A61K9/4816 ,  A61K9/4875 ,  A61K31/34 ,  A61K31/365

摘要： The present invention discloses a novel dosage form of butylphthalide soft capsule and its preparation procedure. Butylphthalide soft capsule is composed of a coating material and a drug-containing oil. The drug-containing oil is basically composed of butylphthalide and diluent—vegetable oil, wherein the weight ratio of butylphthalide to oil ranges from 1:0-10. The coating material is composed of gelatin, plasticizer and water, wherein the weight ratio of gelatin to plasticizer to water is in the range of 1:0.2{tilde over ( )}0.4:0.8{tilde over ( )}0.3. The butylphthalide soft capsule described in this invention can mask the strong and specific flavor of butylphthalide, and overcome the difficulties associated with formulating oily active agents into other oral preparations. The disintegration time of the soft capsule complies with the requirement of Pharmacopoeia of P.R. China.

摘要翻译： 本发明公开了一种丁基苯酞软胶囊的新型剂型及其制备方法。 丁苯酞软胶囊由涂料和含药油组成。 含药油基本上由丁基苯酞和稀释剂 - 植物油组成，其中丁苯酞与油的重量比为1:0-10。 涂料由明胶，增塑剂和水组成，其中明胶与增塑剂与水的重量比在1：0.20.4：0.80.3的范围内。 本发明中描述的丁基苯酞软胶囊可以掩蔽丁苯酞的强烈和特异的风味，并克服与将油性活性剂配制成其它口服制剂相关的困难。 软胶囊的分解时间符合中国药典的药典要求。

公开(公告)号：USD1044295S1

公开(公告)日：2024-10-01

申请号：US29881018

申请日：2022-12-27

申请人： Liyun Liu

设计人： Liyun Liu

摘要： FIG. 1 is a front perspective view of a shoe stool, showing my new design;
FIG. 2 is a rear perspective view thereof;
FIG. 3 is a front elevational view thereof, the rear elevational view is identical;
FIG. 4 is a left side view thereof, the right side view is identical;
FIG. 5 is a top plan view thereof;
FIG. 6 is a bottom plan view thereof; and,
FIG. 7 is a front perspective view of the shoe stool in an exploded state.
The broken lines in the figures are for the purposes of illustrating portions of the shoe stool, which form no part of the claimed design.

公开(公告)号：US20080305163A1

公开(公告)日：2008-12-11

申请号：US12195360

申请日：2008-08-20

申请人： Jianqing Li ,  Min Bai ,  Wenmin Guo ,  Surui Chen ,  Liyun Liu ,  Guirong Zhou

发明人： Jianqing Li ,  Min Bai ,  Wenmin Guo ,  Surui Chen ,  Liyun Liu ,  Guirong Zhou

IPC分类号： A61K31/365 ,  A61K9/48 ,  A61P7/02

CPC分类号： A61K9/4825 ,  A61K9/4816 ,  A61K9/4875 ,  A61K31/34 ,  A61K31/365

摘要： The present invention discloses a novel dosage form of butylphthalide soft capsule and its preparation procedure. Butylphthalide soft capsule is composed of a coating material and a drug-containing oil. The drug-containing oil is basically composed of butylphthalide and diluent—vegetable oil, wherein the weight ratio of butylphthalide to oil ranges from 1:0˜10. The coating material is composed of gelatin, plasticizer and water, wherein the weight ratio of gelatin to plasticizer to water is in the range of 1:0.2˜0.4:0.8˜0.3. The butylphthalide soft capsule described in this invention can mask the strong and specific flavor of butylphthalide, and overcome the difficulties associated with formulating oily active agents into other oral preparations. The disintegration time of the soft capsule complies with the requirement of Pharmacopoeia of P.R. China.

摘要翻译： 本发明公开了一种丁基苯酞软胶囊的新型剂型及其制备方法。 丁苯酞软胶囊由涂料和含药油组成。 含药油基本上由丁苯酞和稀释剂 - 植物油组成，其中丁苯酞与油的重量比为1:0〜10。 涂料由明胶，增塑剂和水组成，其中明胶与增塑剂与水的重量比在1:0.2〜0.4:0.8〜0.3的范围内。 本发明中描述的丁基苯酞软胶囊可以掩蔽丁苯酞的强烈和特异的风味，并克服与将油性活性剂配制成其它口服制剂相关的困难。 软胶囊的分解时间符合中国药典的药典要求。

公开(公告)号：US20070134316A1

公开(公告)日：2007-06-14

申请号：US11445832

申请日：2006-06-02

申请人： Jianqing Li ,  Min Bai ,  Wenmin Guo ,  Surui Chen ,  Liyun Liu ,  Guirong Zhou

发明人： Jianqing Li ,  Min Bai ,  Wenmin Guo ,  Surui Chen ,  Liyun Liu ,  Guirong Zhou

IPC分类号： A61K9/48

CPC分类号： A61K9/4825 ,  A61K9/4816 ,  A61K9/4875 ,  A61K31/34 ,  A61K31/365

摘要： The present invention discloses a novel soft capsule of butylphthalide and a process for preparing the same. The soft capsule of butylphthalide is composed of a capsule wall material and a drug-containing oil, wherein the drug-containing oil is essentially composed of butylphthalide and a vegetable oil as the diluent in a weight ratio of about 1:0˜10. The capsule wall material is composed of a capsule wall matrix, a plasticizer and water in a weight ratio of 1:0.2˜0.4:0.8˜1.3. The soft capsule of butylphthalide described in the present invention can mask the strong and special flavour of butylphthalide, and overcome the difficulties associated with formulating oily active ingredient into other oral formulation. The disintegration time of the soft capsule satisfies the requirement of Pharmacopoeia of P.R. China.

摘要翻译： 本发明公开了一种丁基苯酞的新型软胶囊及其制备方法。 丁基苯酞的软胶囊由胶囊壁材料和药物含油组成，其中药物含油基本上由丁基苯酞和作为稀释剂的植物油组成，重量比为约1:0〜10。 胶囊壁材料由胶囊壁基质，增塑剂和水组成，重量比为1:0.2〜0.4:0.8〜1.3。 本发明中描述的丁基苯酞的软胶囊可以掩蔽丁苯酞的强烈和特殊风味，并克服与将油性活性成分配制成其它口服制剂相关的困难。 软胶囊的分解时间满足中国药典的药典要求。