发明授权
- 专利标题： Nucleic acid molecules encoding A-beta binding polypeptides
- 专利标题（中）： 编码A-β结合多肽的核酸分子
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申请号： US13617248申请日： 2012-09-14
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公开(公告)号： US08614308B2公开(公告)日： 2013-12-24
- 发明人: John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
- 申请人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： DE Ingelheim am Rhein
- 代理商 Michael P. Morris; David L. Kershner
- 优先权： EP10155339 20100303
- 主分类号： C12N15/13
- IPC分类号： C12N15/13 ; C12N5/07 ; C12N5/16 ; C12N1/00 ; C07H21/00
摘要：
The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.
公开/授权文献
- US20130017209A1 A-BETA BINDING POLYPEPTIDES 公开/授权日：2013-01-17
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