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公开(公告)号：US08614308B2
公开(公告)日：2013-12-24
申请号：US13617248
申请日：2012-09-14
申请人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
发明人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.
摘要翻译： 本发明涉及双互补位A-β结合多肽，更具体地涉及包含结合至A-β的不同表位的至少两个免疫球蛋白单可变结构域的双互补位A-β结合多肽。 本发明还涉及这种多肽的具体序列，其生产方法及其使用方法，包括治疗疾病如阿尔茨海默病的方法。
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公开(公告)号：US08337845B2
公开(公告)日：2012-12-25
申请号：US13038471
申请日：2011-03-02
申请人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
发明人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.
摘要翻译： 本发明涉及双互补位A-β结合多肽，更具体地涉及包含结合至A-β的不同表位的至少两个免疫球蛋白单可变结构域的双互补位A-β结合多肽。 本发明还涉及这种多肽的具体序列，其生产方法及其使用方法，包括治疗疾病如阿尔茨海默病的方法。
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公开(公告)号：US07723476B2
公开(公告)日：2010-05-25
申请号：US11224071
申请日：2005-09-13
申请人： Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
发明人： Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
IPC分类号： A61K38/00
CPC分类号： C07K14/43563 , C07K14/435 , C07K14/47 , C07K2299/00 , C07K2318/20 , C07K2319/00 , C12N2799/021
摘要： The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using generic engineering methods. Alike immunoglobulin, the anticalin thus obtained can be used to identify or bond molecular structures.
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公开(公告)号：US07250297B1
公开(公告)日：2007-07-31
申请号：US09509444
申请日：1998-09-25
申请人： Gerald Beste , Thomas Stibora , Arne Skerre , Frank Schmidt
发明人： Gerald Beste , Thomas Stibora , Arne Skerre , Frank Schmidt
CPC分类号： C07K14/43563 , C07K14/435 , C07K14/47 , C07K2299/00 , C07K2318/20 , C07K2319/00 , C12N2799/021
摘要： The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using genetic engineering methods. A like immunoglobulin, the anticalin thus obtained can be used to identify or bond molecular structures.
摘要翻译： 本发明涉及对某些配体表现出结合活性的新蛋白质的生产，即所谓的抗蛋白质。 为此，利用遗传工程方法，通过氨基酸置换在其天然配体结合口袋中修饰脂笼蛋白家族的肽结构。 类似的免疫球蛋白，所得到的anticalin可用于鉴定或结合分子结构。
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公开(公告)号：US09932403B2
公开(公告)日：2018-04-03
申请号：US13698992
申请日：2011-05-20
申请人： Christine Knuehl , Bjoern Hock , Robert Hofmeister , Gerald Beste , Hilde Adi Pierrette Revets , Frank Kamiel Delphina Verdonck , Sigrid Godelieve Victor Cornelis
发明人： Christine Knuehl , Bjoern Hock , Robert Hofmeister , Gerald Beste , Hilde Adi Pierrette Revets , Frank Kamiel Delphina Verdonck , Sigrid Godelieve Victor Cornelis
CPC分类号： C07K16/2863 , A61K2039/505 , A61P35/00 , C07K16/18 , C07K16/32 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： The present disclosure relates to amino acid sequences that are directed against (as defined herein) HER3, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences (also referred to herein as “amino acid sequences of the invention”, “compounds of the invention”, and “polypeptides of the invention”, respectively). The disclosure also relates to nucleic acids encoding such amino acid sequences and polypeptides (also referred to herein as “nucleic acids of the invention” or “nucleotide sequences of the invention”); to methods for 10 preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes mentioned herein.
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公开(公告)号：US20110117113A1
公开(公告)日：2011-05-19
申请号：US12897051
申请日：2010-10-04
申请人： Gerald Beste , Stephanie Staelens , Peter Vanlandschoot , Maria Gonzalez Pajuelo , Hilde Adi Pierrette Revets , Peter Schotte , Hilde Stals , Ann Brige , Maarten Dewilde , Catelijne Stortelers
发明人： Gerald Beste , Stephanie Staelens , Peter Vanlandschoot , Maria Gonzalez Pajuelo , Hilde Adi Pierrette Revets , Peter Schotte , Hilde Stals , Ann Brige , Maarten Dewilde , Catelijne Stortelers
IPC分类号： A61K39/395 , C07K16/28 , C07K16/46 , C07K19/00 , A61P35/00 , A61P35/02 , A61P35/04 , A61P29/00 , A61P31/00 , A61P17/06 , A61P11/06 , A61P11/00 , A61P37/06
CPC分类号： C07K16/2866 , C07K16/00 , C07K2317/22 , C07K2317/31 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The invention relates to immunoglobulin single variable domains directed against specific human CXCR4 epitopes (herein also referred to interchangeably as “compounds of the invention”, “amino acid sequences of the invention”, or “building blocks of the invention”) and polypeptides comprising them (herein also referred to as “polypeptides of the invention”, “compounds of the invention”, or “constructs of the invention”).Furthermore, the present invention relates to nucleic acids encoding the compounds of the invention (also referred to herein as “nucleic acids of the invention” or “nucleotide sequences of the invention”); to methods for preparing the compounds of the invention; to host cells expressing or capable of expressing the compounds of the invention; to compositions, and in particular to pharmaceutical compositions, that comprise the compounds of the invention; and to uses of the compounds of the invention and the aforementioned nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes mentioned herein.The invention also relates to methods for generating immunoglobulin single variable domains against a target such as a cell-associated protein and constructs comprising said immunoglobulin single variable domains. The invention also provides immunoglobulin single variable domains obtainable by the methods of the invention. Specifically, the present invention relates to the generation of immunoglobulin single variable domains and constructs thereof by use of epitope walking with multimer libraries. More specifically, the present invention relates to the generation of immunoglobulin single variable domains derived from camelids directed against a particular epitope of a target, in particular against a target with multiple transmembrane spanning domains, including GPCRs and ion channels, by epitope walking with multimer libraries.
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公开(公告)号：US20180009888A9
公开(公告)日：2018-01-11
申请号：US14128681
申请日：2012-06-25
申请人： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Neotere Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
发明人： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Neotere Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
CPC分类号： C07K16/28 , C07K16/00 , C07K16/4283 , C07K2317/22 , C07K2317/569 , C07K2317/94 , C07K2319/30 , G01N33/6854
摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; —methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; —modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.
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公开(公告)号：US08703135B2
公开(公告)日：2014-04-22
申请号：US13435567
申请日：2012-03-30
申请人： Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Cedric Jozef Neotere Ververken , Tinneke Denayer
发明人： Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Cedric Jozef Neotere Ververken , Tinneke Denayer
IPC分类号： A61K39/395 , C12P21/08 , C07K16/18 , C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/18 , C07K2317/22 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12Q1/6876 , G01N33/53
摘要： The present invention relates to biological materials related to c-Met possibly in combination with VEGF and/or EGFR, and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. Methods and kits for assessing the responsiveness of a patient to c-Met therapy are also described and provided.
摘要翻译： 本发明涉及与可能与VEGF和/或EGFR组合的c-Met相关的生物学材料，更具体地涉及编码这些多肽的多肽，核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。 还描述和提供了用于评估患者对c-Met治疗的反应性的方法和试剂盒。
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公开(公告)号：US20120244164A1
公开(公告)日：2012-09-27
申请号：US13435567
申请日：2012-03-30
申请人： Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Cedric Jozef Neotere Ververken , Tinneke Denayer
发明人： Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Cedric Jozef Neotere Ververken , Tinneke Denayer
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/18 , C07K2317/22 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12Q1/6876 , G01N33/53
摘要： The present invention relates to biological materials related to c-Met possibly in combination with VEGF and/or EGFR, and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. Methods and kits for assessing the responsiveness of a patient to c-Met therapy are also described and provided.
摘要翻译： 本发明涉及与可能与VEGF和/或EGFR组合的c-Met相关的生物学材料，更具体地涉及编码这些多肽的多肽，核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。 还描述和提供了用于评估患者对c-Met治疗的反应性的方法和试剂盒。
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公开(公告)号：US20100285564A1
公开(公告)日：2010-11-11
申请号：US12654809
申请日：2010-01-05
申请人： Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
发明人： Arne Skerra , Gerald Beste , Frank Schmidt , Thomas Stibora
CPC分类号： C07K14/43563 , C07K14/435 , C07K14/47 , C07K2299/00 , C07K2318/20 , C07K2319/00 , C12N2799/021
摘要： The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using generic engineering methods. Alike immunoglobulin, the anticalin thus obtained can be used to identify or bond molecular structures.
摘要翻译： 本发明涉及对某些配体表现出结合活性的新蛋白质的生产，即所谓的抗蛋白质。 为此，脂笼蛋白家族的肽结构通过使用通用工程方法的天然配体结合口袋中的氨基酸替换来修饰。 如此获得的相似免疫球蛋白可以用于鉴定或结合分子结构。
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