发明授权
- 专利标题： Exo- and diastereo-selective synthesis of himbacine analogs
- 专利标题（中）： 烟草类似物的外切和非对映选择性合成
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申请号： US13563136申请日： 2012-07-31
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公开(公告)号： US08618314B2公开(公告)日： 2013-12-31
- 发明人: George G. Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank X. Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Illia Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
- 申请人： George G. Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank X. Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Illia Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Mark W. Russell; Catherine D. Fitch
- 主分类号： C07D307/92
- IPC分类号： C07D307/92
摘要：
This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
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