发明授权
US08629255B2 Nucleic acid molecules conferring enhanced ethanol tolerance and microorganisms having enhanced tolerance to ethanol
有权
赋予提高乙醇耐受性的核酸分子和对乙醇具有增强耐受性的微生物
- 专利标题： Nucleic acid molecules conferring enhanced ethanol tolerance and microorganisms having enhanced tolerance to ethanol
- 专利标题（中）： 赋予提高乙醇耐受性的核酸分子和对乙醇具有增强耐受性的微生物
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申请号： US13112641申请日： 2011-05-20
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公开(公告)号： US08629255B2公开(公告)日： 2014-01-14
- 发明人: Steven Brown , Adam Guss , Shihui Yang , Tatiana Karpinets , Lee Lynd , Xiongjun Shao
- 申请人： Steven Brown , Adam Guss , Shihui Yang , Tatiana Karpinets , Lee Lynd , Xiongjun Shao
- 申请人地址： US TN Oak Ridge
- 专利权人： UT-Battelle, LLC
- 当前专利权人： UT-Battelle, LLC
- 当前专利权人地址： US TN Oak Ridge
- 代理机构： Scully, Scott, Murphy & Presser, P.C.
- 主分类号： C07H21/00
- IPC分类号： C07H21/00 ; C12P7/02 ; C12N1/00 ; C12N15/75 ; C12N1/15
摘要：
The present invention provides isolated nucleic acid molecules which encode a mutant acetaldehyde-CoA/alcohol dehydrogenase or mutant alcohol dehydrogenase and confer enhanced tolerance to ethanol. The invention also provides related expression vectors, genetically engineered microorganisms having enhanced tolerance to ethanol, as well as methods of making and using such genetically modified microorganisms for production of biofuels based on fermentation of biomass materials.
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