发明授权
- 专利标题: Antimicrobial compositions, methods of preparation thereof, and uses thereof
- 专利标题(中): 抗微生物组合物,其制备方法及其用途
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申请号: US13077005申请日: 2011-03-31
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公开(公告)号: US08642086B2公开(公告)日: 2014-02-04
- 发明人: Daniel Joseph Coady , Kazuki Fukushima , James Lupton Hedrick , Yi Yan Yang
- 申请人: Daniel Joseph Coady , Kazuki Fukushima , James Lupton Hedrick , Yi Yan Yang
- 申请人地址: US NY Armonk SG Singapore
- 专利权人: International Business Machines Corporation,Agency for Science, Technology and Research
- 当前专利权人: International Business Machines Corporation,Agency for Science, Technology and Research
- 当前专利权人地址: US NY Armonk SG Singapore
- 代理商 Michael R. Roberts
- 主分类号: A61K9/00
- IPC分类号: A61K9/00 ; A61K31/765
摘要:
A composition of matter comprises a cationic polymer comprising a polycarbonate chain fragment, the polycarbonate chain fragment comprising a repeat unit comprising a side chain moiety containing a quaternary amine group; and a non-charged polymer comprising a polyester chain segment and a poly(alkylene oxide) chain segment; wherein i) the cationic polymer and the non-charged polymer are amphiphilic and biocompatible, ii) the cationic polymer and the non-charged polymer form a mixed complex by non-covalent interactions in water, and iii) the mixed complex is a more effective antimicrobial agent against at least a Gram-negative microbe compared to the cationic polymer and the non-charged polymer alone when tested using otherwise identical conditions.