发明授权
- 专利标题： Humanized FcγR mice
- 专利标题（中）： 人源化FcgammaR小鼠
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申请号： US12971080申请日： 2010-12-17
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公开(公告)号： US08658154B2公开(公告)日： 2014-02-25
- 发明人: Lynn MacDonald , Naxin Tu , Cagan Gurer , Sean Stevens , Andrew J. Murphy
- 申请人： Lynn MacDonald , Naxin Tu , Cagan Gurer , Sean Stevens , Andrew J. Murphy
- 申请人地址： US NY Tarrytown
- 专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人地址： US NY Tarrytown
- 代理商 Brenda Herschbach Jarrell; Kevin J. Pobursky; Nathan A. Billings
- 主分类号： A01N63/00
- IPC分类号： A01N63/00 ; A01N65/00
摘要：
Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided.
公开/授权文献
- US20110154512A1 Humanized Fc gamma R Mice 公开/授权日：2011-06-23
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