发明授权
- 专利标题: Carbon nanotube compositions and methods of use thereof
- 专利标题(中): 碳纳米管组合物及其使用方法
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申请号: US12933223申请日: 2009-03-19
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公开(公告)号: US08658178B2公开(公告)日: 2014-02-25
- 发明人: Tarek M. Fahmy , Lisa D. Pfefferle , Gary L. Haller
- 申请人: Tarek M. Fahmy , Lisa D. Pfefferle , Gary L. Haller
- 申请人地址: US CT New Haven
- 专利权人: Yale University
- 当前专利权人: Yale University
- 当前专利权人地址: US CT New Haven
- 代理机构: Pabst Patent Group LLP
- 国际申请: PCT/US2009/037727 WO 20090319
- 国际公布: WO2009/117616 WO 20090924
- 主分类号: A61K39/385
- IPC分类号: A61K39/385 ; C12N5/071 ; C12P21/08 ; C07K16/00
摘要:
Carbon nanotube (CNT)-based compositions for activating cellular immune responses are provided. The CNTs function as high surface area scaffolds for the attachment of T cell ligands and/or antigens. The CNT compositions function as artificial antigen-presenting cells (aAPCs) or as modular vaccines. The disclosed CNT aAPCs are efficient at activating T cells and may be used to activate T cells ex vivo or in vivo for adoptive or active immunotherapy.
公开/授权文献
- US20110014217A1 CARBON NANOTUBE COMPOSITIONS AND METHODS OF USE THEREOF 公开/授权日:2011-01-20
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