发明授权
- 专利标题： Low affinity FcγR deficient mice
- 专利标题（中）： 低亲和力FcgammaR缺陷小鼠
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申请号： US13466225申请日： 2012-05-08
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公开(公告)号： US08658853B2公开(公告)日： 2014-02-25
- 发明人: Lynn Macdonald , Naxin Tu , Cagan Gurer , Sean Stevens , Andrew J Murphy
- 申请人： Lynn Macdonald , Naxin Tu , Cagan Gurer , Sean Stevens , Andrew J Murphy
- 申请人地址： US NY Tarrytown
- 专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人地址： US NY Tarrytown
- 代理商 Brenda Herschbach Jarrell; Kevin J. Pobursky; Nathan A. Billings
- 主分类号： A01K67/027
- IPC分类号： A01K67/027 ; C12N5/00 ; C12N5/02
摘要：
Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided.
公开/授权文献
- US20120260357A1 Low Affinity FcgR Deficient Mice 公开/授权日：2012-10-11
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