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    Anti-ANGPTL3 antibodies and uses thereof
    2.
    发明授权
    Anti-ANGPTL3 antibodies and uses thereof 有权
    抗ANGPTL3抗体及其用途

    公开(公告)号：US09018356B2

    公开(公告)日：2015-04-28

    申请号：US13517662

    申请日：2012-06-14

    申请人： Mark W. Sleeman ,  Viktoria Gusarova ,  Andrew J. Murphy

    发明人： Mark W. Sleeman ,  Viktoria Gusarova ,  Andrew J. Murphy

    IPC分类号： C07K16/00 ,  C07K16/46 ,  C07K16/24 ,  C07K16/22 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

    CPC分类号： C07K16/22 ,  A61K31/455 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

    摘要： A fully human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits or interferes with at least one activity of human angiopoietin-like protein 3 (hANGPTL3) is provided. The human anti-hANGPTL3 antibodies are useful in treating diseases or disorders associated with ANGPTL3, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, chylomicronemia, and so forth. Furthermore, the anti-hANGPTL3 antibodies can be administered to a subject in need thereof to prevent or treat diseases or disorders, for which abnormal lipid metabolism is a risk factor. Such diseases or disorders include cardiovascular diseases, such as atherosclerosis and coronary artery diseases; acute pancreatitis; nonalcoholic steatohepatitis (NASH); diabetes; obesity; and the like.

    摘要翻译： 提供了特异性结合并抑制或干扰人类血管生成素样蛋白3（hANGPTL3）的至少一种活性的人抗体的完全人抗体或抗原结合片段。 人抗hANGPTL3抗体可用于治疗与ANGPTL3相关的疾病或病症，例如高脂血症，高脂蛋白血症和血脂异常，包括高甘油三酯血症，高胆固醇血症，乳糜微血症等。 此外，可以将抗hANGPTL3抗体施用于有需要的受试者，以预防或治疗脂代谢异常是危险因素的疾病或病症。 这些疾病或病症包括心血管疾病，例如动脉粥样硬化和冠状动脉疾病; 急性胰腺炎 非酒精性脂肪性肝炎（NASH）; 糖尿病; 肥胖; 等等。

    Mice expressing human voltage-gated sodium channels
    3.
    发明授权
    Mice expressing human voltage-gated sodium channels 有权
    表达人电压门控钠通道的小鼠

    公开(公告)号：US08871996B2

    公开(公告)日：2014-10-28

    申请号：US13155491

    申请日：2011-06-08

    申请人： Lynn Macdonald ,  Andrew J. Murphy ,  Michael L. LaCroix-Fralish ,  Nicole M. Alessandri Haber

    发明人： Lynn Macdonald ,  Andrew J. Murphy ,  Michael L. LaCroix-Fralish ,  Nicole M. Alessandri Haber

    IPC分类号： A01K67/027

    CPC分类号： A01K67/0278 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/0356

    摘要： Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a humanization of an extracellular loop of an endogenous NaV channel gene, in particular a humanization of the one or more extracellular pore loops of a NaV1.7 channel protein. Genetically modified non-human animals are also provided, wherein the genetic modification comprises replacement of an endogenous NaV channel gene, in particular a replacement of the endogenous NaV1.7 gene with a human NaV1.7 gene, and wherein the genetically modified non-human animals are capable of generating action potentials and communicating through the excitable cells of the genetically modified non-human animals via the expressed human or humanized NaV1.7 protein the surface of the excitable cells. Genetically modified mice are described, including mice that express the human or humanized NaV1.7 gene from the endogenous NaV1.7 locus, and wherein the mice comprise functional β-subunits.

    摘要翻译： 提供了遗传修饰的非人动物以及用于制备和使用它们的方法和组合物，其中所述遗传修饰包括内源性NaV通道基因的细胞外环的人源化，特别是一种或多种细胞外孔环的人源化 NaV1.7通道蛋白。 还提供了遗传修饰的非人动物，其中遗传修饰包括内源性NaV通道基因的替换，特别是用人NaV1.7基因替代内源性NaV1.7基因，并且其中所述遗传修饰的非人动物 动物能够通过表达的人或人源化NaV1.7蛋白质产生动力电位并通过基因修饰的非人动物的可兴奋细胞进行通信，所述可激活细胞的表面。 描述了转基因小鼠，包括从内源性NaV1.7基因座表达人或人源化NaV1.7基因的小鼠，其中小鼠包含功能性和亚基。

    ADAM6 mice
    5.
    发明授权
    ADAM6 mice 有权
    ADAM6小鼠

    公开(公告)号：US08642835B2

    公开(公告)日：2014-02-04

    申请号：US13404075

    申请日：2012-02-24

    申请人： Lynn MacDonald ,  Sean Stevens ,  Andrew J. Murphy

    发明人： Lynn MacDonald ,  Sean Stevens ,  Andrew J. Murphy

    IPC分类号： C12N5/10 ,  C12P21/00 ,  A01K67/00

    CPC分类号： C07K16/40 ,  A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  C07K16/22 ,  C07K16/28 ,  C07K16/2866 ,  C07K16/461 ,  C07K16/462 ,  C07K2317/21 ,  C07K2317/92 ,  C12N9/6489 ,  C12N15/8509 ,  C12N2800/204 ,  C12N2800/30

    摘要： Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.

    摘要翻译： 提供了包含来自内源性ADAM6基因座的ADAM6活性的减少或缺失或缺少编码小鼠ADAM6蛋白的内源性基因座的小鼠，其中所述小鼠包含编码ADAM6或直系同源物或其同源物或其片段的序列，其功能在 一只雄性老鼠 在一个实施方案中，序列是异位ADAM6序列或赋予雄性小鼠通过交配产生后代的能力的序列。 还提供了具有遗传修饰的免疫球蛋白重链基因座的小鼠和细胞，其包含编码小鼠ADAM6或其功能片段或同源物或直系同源物的异位核苷酸序列。