发明授权
US08685396B2 Monoclonal antibodies that neutralize anthrax protective antigen (PA) toxin
有权
中和炭疽保护性抗原（PA）毒素的单克隆抗体
- 专利标题： Monoclonal antibodies that neutralize anthrax protective antigen (PA) toxin
- 专利标题（中）： 中和炭疽保护性抗原（PA）毒素的单克隆抗体
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申请号： US11793735申请日： 2005-12-21
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公开(公告)号： US08685396B2公开(公告)日： 2014-04-01
- 发明人: Zhaochun Chen , Stephen Leppla , Mahtab Moayeri , Suzanne U. Emerson , Robert H. Purcell
- 申请人： Zhaochun Chen , Stephen Leppla , Mahtab Moayeri , Suzanne U. Emerson , Robert H. Purcell
- 申请人地址： US DC Washington
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Sheridan Ross P.C.
- 国际申请： PCT/US2005/046790 WO 20051221
- 国际公布： WO2007/084107 WO 20070726
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/00 ; C07H21/04 ; C12N5/10 ; G01N33/53
摘要：
The present invention relates to monoclonal antibodies that bind or neutralize anthrax protective antigen (PA) toxin. The invention provides such antibodies, fragments of such antibodies retaining anthrax PA toxin-binding ability, fully human or humanized antibodies retaining anthrax PA toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
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