Invention Grant
US08697348B2 Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571
有权
与STI-571抗性相关的Bcr-Abl酪氨酸激酶突变
- Patent Title: Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571
- Patent Title (中): 与STI-571抗性相关的Bcr-Abl酪氨酸激酶突变
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Application No.: US11485023Application Date: 2006-07-12
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Publication No.: US08697348B2Publication Date: 2014-04-15
- Inventor: Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll
- Applicant: Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll
- Applicant Address: US CA Oakland
- Assignee: The Regent of the University of California
- Current Assignee: The Regent of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Ropes & Gray LLP
- Agent James F. Haley, Jr.; Qianru Li
- Main IPC: C12Q1/00
- IPC: C12Q1/00 ; C12Q1/68 ; G01N33/53 ; G01N33/574 ; G01N33/00
Abstract:
The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
Public/Granted literature
- US20060269956A1 Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571 Public/Granted day:2006-11-30
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