发明授权
- 专利标题: Method of preparing enteric hard capsule and enteric hard capsule prepared thereby
- 专利标题(中): 制备肠溶硬胶囊和肠溶硬胶囊的方法
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申请号: US13634590申请日: 2011-02-21
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公开(公告)号: US08710105B2公开(公告)日: 2014-04-29
- 发明人: Jin Ryul Son , Hyon Ho Baek , Eun Hee Park , Sung Wan Lee , Min Gyu Song , Ja Hyun Cha , Jae Uk Cha , Won Hwa Ko
- 申请人: Jin Ryul Son , Hyon Ho Baek , Eun Hee Park , Sung Wan Lee , Min Gyu Song , Ja Hyun Cha , Jae Uk Cha , Won Hwa Ko
- 申请人地址: KR
- 专利权人: Samsung Fine Chemicals Co., Ltd.
- 当前专利权人: Samsung Fine Chemicals Co., Ltd.
- 当前专利权人地址: KR
- 代理机构: Cantor Colburn LLP
- 优先权: KR10-2010-0055470 20100611
- 国际申请: PCT/KR2011/001118 WO 20110221
- 国际公布: WO2011/155686 WO 20111215
- 主分类号: A61K47/38
- IPC分类号: A61K47/38
摘要:
A method of preparing enteric hard capsules, and an enteric hard capsule prepared by the method. The method may include: dissolving an enteric base material, a capsule forming aid, and a neutralizing agent in water at room temperature to prepare an aqueous composition; heating the aqueous composition to a first temperature that is higher than a gelation start temperature of the aqueous composition; cooling the heated aqueous composition to a second temperature that is lower than the gelation start temperature; immersing a mold pin heated to a third temperature that is higher than the gelation start temperature into the aqueous composition; removing the mold pin from the aqueous composition to obtain a film coated on the mold pin; maintaining the film on the mold pin at a fourth temperature that is higher than the gelation start temperature for a first time period to fix the film onto the mold pin; and drying the fixed film at a fifth temperature for a second time period to obtain a capsule shell.
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