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    METHOD OF PREPARAING ENTERIC HARD CAPSULE AND ENTERIC HARD CAPSULE PREPARED THEREBY
    2.
    发明申请
    METHOD OF PREPARAING ENTERIC HARD CAPSULE AND ENTERIC HARD CAPSULE PREPARED THEREBY 有权
    制备肠溶硬胶囊和肠内硬化胶囊的方法

    公开(公告)号：US20130072579A1

    公开(公告)日：2013-03-21

    申请号：US13634590

    申请日：2011-02-21

    申请人： Jin Ryul Son ,  Hyon Ho Baek ,  Eun Hee Park ,  Sung Wan Lee ,  Min Gyu Song ,  Ja Hyun Cha ,  Jae Uk Cha ,  Won Hwa Ko

    发明人： Jin Ryul Son ,  Hyon Ho Baek ,  Eun Hee Park ,  Sung Wan Lee ,  Min Gyu Song ,  Ja Hyun Cha ,  Jae Uk Cha ,  Won Hwa Ko

    IPC分类号： A61K47/38

    CPC分类号： A61K47/38 ,  A61J3/077 ,  A61K9/4816

    摘要： A method of preparing enteric hard capsules, and an enteric hard capsule prepared by the method. The method may include: dissolving an enteric base material, a capsule forming aid, and a neutralizing agent in water at room temperature to prepare an aqueous composition; heating the aqueous composition to a first temperature that is higher than a gelation start temperature of the aqueous composition; cooling the heated aqueous composition to a second temperature that is lower than the gelation start temperature; immersing a mold pin heated to a third temperature that is higher than the gelation start temperature into the aqueous composition; removing the mold pin from the aqueous composition to obtain a film coated on the mold pin; maintaining the film on the mold pin at a fourth temperature that is higher than the gelation start temperature for a first time period to fix the film onto the mold pin; and drying the fixed film at a fifth temperature for a second time period to obtain a capsule shell.

    摘要翻译： 制备肠溶硬胶囊的方法和通过该方法制备的肠溶硬胶囊。 该方法可以包括：在室温下将肠溶基质材料，胶囊形成助剂和中和剂溶于水中以制备含水组合物; 将所述水性组合物加热到高于所述水性组合物的凝胶化开始温度的第一温度; 将加热的水性组合物冷却至低于凝胶化开始温度的第二温度; 将加热到高于凝胶化开始温度的第三温度的模具针浸入水性组合物中; 从水性组合物中取出模具销以获得涂在模具销上的薄膜; 在第一温度高于第一时间的凝胶化开始温度的第四温度下将薄膜保持在模具销上，以将薄膜固定在模具销上; 并在第五温度下将固定膜干燥第二时间以获得胶囊壳。

    Method of preparing enteric hard capsule and enteric hard capsule prepared thereby
    5.
    发明授权
    Method of preparing enteric hard capsule and enteric hard capsule prepared thereby 有权
    制备肠溶硬胶囊和肠溶硬胶囊的方法

    公开(公告)号：US08710105B2

    公开(公告)日：2014-04-29

    申请号：US13634590

    申请日：2011-02-21

    申请人： Jin Ryul Son ,  Hyon Ho Baek ,  Eun Hee Park ,  Sung Wan Lee ,  Min Gyu Song ,  Ja Hyun Cha ,  Jae Uk Cha ,  Won Hwa Ko

    发明人： Jin Ryul Son ,  Hyon Ho Baek ,  Eun Hee Park ,  Sung Wan Lee ,  Min Gyu Song ,  Ja Hyun Cha ,  Jae Uk Cha ,  Won Hwa Ko

    IPC分类号： A61K47/38

    CPC分类号： A61K47/38 ,  A61J3/077 ,  A61K9/4816

    摘要： A method of preparing enteric hard capsules, and an enteric hard capsule prepared by the method. The method may include: dissolving an enteric base material, a capsule forming aid, and a neutralizing agent in water at room temperature to prepare an aqueous composition; heating the aqueous composition to a first temperature that is higher than a gelation start temperature of the aqueous composition; cooling the heated aqueous composition to a second temperature that is lower than the gelation start temperature; immersing a mold pin heated to a third temperature that is higher than the gelation start temperature into the aqueous composition; removing the mold pin from the aqueous composition to obtain a film coated on the mold pin; maintaining the film on the mold pin at a fourth temperature that is higher than the gelation start temperature for a first time period to fix the film onto the mold pin; and drying the fixed film at a fifth temperature for a second time period to obtain a capsule shell.

    摘要翻译： 制备肠溶硬胶囊的方法和通过该方法制备的肠溶硬胶囊。 该方法可以包括：在室温下将肠溶基质材料，胶囊形成助剂和中和剂溶于水中以制备含水组合物; 将所述水性组合物加热到高于所述水性组合物的凝胶化开始温度的第一温度; 将加热的水性组合物冷却至低于凝胶化开始温度的第二温度; 将加热到高于凝胶化开始温度的第三温度的模具针浸入水性组合物中; 从水性组合物中取出模具销以获得涂在模具销上的薄膜; 在第一温度高于第一时间的凝胶化开始温度的第四温度下将薄膜保持在模具销上，以将薄膜固定在模具销上; 并在第五温度下将固定膜干燥第二时间以获得胶囊壳。