发明授权
- 专利标题： Conformationally stabilized HIV envelope immunogens
- 专利标题（中）： 构象稳定的HIV包膜免疫原
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申请号： US13585700申请日： 2012-08-14
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公开(公告)号： US08715686B2公开(公告)日： 2014-05-06
- 发明人: Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
- 申请人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
- 申请人地址： US DC Washington US MA Boston
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services,Dana-Faber Cancer Institute, Inc.
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services,Dana-Faber Cancer Institute, Inc.
- 当前专利权人地址： US DC Washington US MA Boston
- 代理机构： Klarquist Sparkman, LLP
- 主分类号： A61K39/21
- IPC分类号： A61K39/21
摘要：
Isolated immunogens including a HIV-1 gp120 polypeptide or immunogenic fragment thereof stabilized in a CD4 bound confirmation by crosslinked cysteines, and methods of their use are disclosed. The immunogens are useful, for example, for generating an immune response to HIV-1 gp120 in a subject.
公开/授权文献
- US20120328641A1 CONFORMATIONALLY STABILIZED HIV ENVELOPE IMMUNOGENS 公开/授权日：2012-12-27
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