发明授权
- 专利标题: Monoclonal antibody against oxidized low-density lipoprotein
- 专利标题(中): 抗氧化低密度脂蛋白的单克隆抗体
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申请号: US13695043申请日: 2011-04-28
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公开(公告)号: US08729240B2公开(公告)日: 2014-05-20
- 发明人: Hitoshi Chiba , Seiichi Kobayashi , Hiroyuki Furukawa
- 申请人: Hitoshi Chiba , Seiichi Kobayashi , Hiroyuki Furukawa
- 申请人地址: JP Hokkaido
- 专利权人: National University Corporation Hokkaido University
- 当前专利权人: National University Corporation Hokkaido University
- 当前专利权人地址: JP Hokkaido
- 代理机构: RatnerPrestia
- 优先权: JP2010-103663 20100428
- 国际申请: PCT/JP2011/060376 WO 20110428
- 国际公布: WO2011/136332 WO 20111103
- 主分类号: C07K16/00
- IPC分类号: C07K16/00
摘要:
Provided is a monoclonal antibody against slightly oxidized LDL, which can play a role as an important tool in the research and development of oxidized LDL. Also provided are a kit for the simple detection of slightly oxidized LDL and a method for the simple detection of slightly oxidized LDL from the biological sample of a subject to be tested which use the monoclonal antibody. By means of ELISA (Enzyme-Linked Immunosorbent Assay) using the monoclonal antibody as the solid phase antibody and an anti-apolipoprotein B antibody as the detection antibody, the degree of reaction between a severely oxidized low-density lipoprotein and the monoclonal antibody is low in comparison to the degree of reaction between a slightly oxidized low-density lipoprotein and the monoclonal antibody, and the monoclonal antibody specifically reacts with an oxidized low-density lipoprotein.
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