Invention Grant
US08742083B1 Panel of micrornas that silence the MCL-1 gene and sensitize cancer cells to ABT-263
有权
将微绒毛组织沉默MCL-1基因并使癌细胞对ABT-263敏感
- Patent Title: Panel of micrornas that silence the MCL-1 gene and sensitize cancer cells to ABT-263
- Patent Title (中): 将微绒毛组织沉默MCL-1基因并使癌细胞对ABT-263敏感
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Application No.: US12978086Application Date: 2010-12-23
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Publication No.: US08742083B1Publication Date: 2014-06-03
- Inventor: Dimitri Semizarov , Xin Lu , Lloyd T. Lam
- Applicant: Dimitri Semizarov , Xin Lu , Lloyd T. Lam
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Agency: Michael Best & Friedrich LLP
- Agent Lisa V. Mueller
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07H21/02 ; C07H21/04
Abstract:
MicroRNAs (miRNAs) that sensitize cancer cells to Bcl-2 family protein inhibitors are identified and described. Oligonucleotide panels, arrays and methods using the sensitizing miRNAs are also disclosed.
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