发明授权
- 专利标题： Histone deacetylase inhibitors and methods of use thereof
- 专利标题（中）： 组蛋白脱乙酰酶抑制剂及其使用方法
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申请号： US13551086申请日： 2012-07-17
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公开(公告)号： US08748463B2公开(公告)日： 2014-06-10
- 发明人: Alan P. Kozikowski , Anatoly Dritschilo , Mira Jung , Pavel A. Petukhov , Bin Chen
- 申请人： Alan P. Kozikowski , Anatoly Dritschilo , Mira Jung , Pavel A. Petukhov , Bin Chen
- 申请人地址： US DC Washington
- 专利权人： Georgetown University
- 当前专利权人： Georgetown University
- 当前专利权人地址： US DC Washington
- 代理机构： Foley Hoag LLP
- 主分类号： A61K31/16
- IPC分类号： A61K31/16 ; C07D277/02 ; C07D263/02 ; C07C233/08 ; C07C233/14
摘要：
The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.