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公开(公告)号:US08748463B2
公开(公告)日:2014-06-10
申请号:US13551086
申请日:2012-07-17
IPC分类号: A61K31/16 , C07D277/02 , C07D263/02 , C07C233/08 , C07C233/14
CPC分类号: C07C271/02 , A61K31/19 , C07C259/06 , C07C275/24 , C07C275/26 , C07C275/40 , C07C323/44 , C07C323/60 , C07C2603/74 , C07D215/48 , C07D215/54
摘要: The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
摘要翻译: 本发明提供了新型的HDAC抑制剂。 还提供了使癌细胞对放射治疗的细胞毒作用敏感的方法以及治疗癌症的方法和治疗神经疾病的方法。 另外,本发明还提供了包含本发明的HDAC抑制剂的药物组合物和包含含有本发明的HDAC抑制剂的容器的试剂盒。
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公开(公告)号:US07842835B2
公开(公告)日:2010-11-30
申请号:US10614498
申请日:2003-07-07
IPC分类号: C07C275/04 , A61K31/17
CPC分类号: C07C271/02 , A61K31/19 , C07C259/06 , C07C275/24 , C07C275/26 , C07C275/40 , C07C323/44 , C07C323/60 , C07C2603/74 , C07D215/48 , C07D215/54
摘要: The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
摘要翻译: 本发明提供了新型的HDAC抑制剂。 还提供了使癌细胞对放射治疗的细胞毒作用敏感的方法以及治疗癌症的方法和治疗神经疾病的方法。 另外,本发明还提供了包含本发明的HDAC抑制剂的药物组合物和包含含有本发明的HDAC抑制剂的容器的试剂盒。
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公开(公告)号:US20130065963A1
公开(公告)日:2013-03-14
申请号:US13551086
申请日:2012-07-17
IPC分类号: A61K31/16 , A61K31/17 , C07C275/40 , C07C275/26 , A61P25/00 , C07C233/06 , C07C233/07 , A61K31/167 , A61P35/00 , C07C275/24 , C07C275/28
CPC分类号: C07C271/02 , A61K31/19 , C07C259/06 , C07C275/24 , C07C275/26 , C07C275/40 , C07C323/44 , C07C323/60 , C07C2603/74 , C07D215/48 , C07D215/54
摘要: The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
摘要翻译: 本发明提供了新型的HDAC抑制剂。 还提供了使癌细胞对放射治疗的细胞毒作用敏感的方法以及治疗癌症的方法和治疗神经疾病的方法。 另外,本发明还提供了包含本发明的HDAC抑制剂的药物组合物和包含含有本发明的HDAC抑制剂的容器的试剂盒。
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公开(公告)号:US20110098504A1
公开(公告)日:2011-04-28
申请号:US12911145
申请日:2010-10-25
IPC分类号: C07C275/28 , C07C275/18 , C07C237/00
CPC分类号: C07C271/02 , A61K31/19 , C07C259/06 , C07C275/24 , C07C275/26 , C07C275/40 , C07C323/44 , C07C323/60 , C07C2603/74 , C07D215/48 , C07D215/54
摘要: The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
摘要翻译: 本发明提供了新型的HDAC抑制剂。 还提供了使癌细胞对放射治疗的细胞毒作用敏感的方法以及治疗癌症的方法和治疗神经疾病的方法。 另外,本发明还提供了包含本发明的HDAC抑制剂的药物组合物和包含含有本发明的HDAC抑制剂的容器的试剂盒。
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公开(公告)号:US08222451B2
公开(公告)日:2012-07-17
申请号:US12911145
申请日:2010-10-25
IPC分类号: C07C275/04 , C07C275/22 , A61K31/155 , A61K31/16
CPC分类号: C07C271/02 , A61K31/19 , C07C259/06 , C07C275/24 , C07C275/26 , C07C275/40 , C07C323/44 , C07C323/60 , C07C2603/74 , C07D215/48 , C07D215/54
摘要: The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
摘要翻译: 本发明提供了新型的HDAC抑制剂。 还提供了使癌细胞对放射治疗的细胞毒作用敏感的方法以及治疗癌症的方法和治疗神经疾病的方法。 另外,本发明还提供了包含本发明的HDAC抑制剂的药物组合物和包含含有本发明的HDAC抑制剂的容器的试剂盒。
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公开(公告)号:US08653278B2
公开(公告)日:2014-02-18
申请号:US12375348
申请日:2007-08-02
申请人: Alan P. Kozikowski , Mira Jung , Anatoly Dritschilo , Arsen Gaysin , Pavel A. Petukhov , Werner Tueckmantel , Hongbin Yuan , Yufeng Chen
发明人: Alan P. Kozikowski , Mira Jung , Anatoly Dritschilo , Arsen Gaysin , Pavel A. Petukhov , Werner Tueckmantel , Hongbin Yuan , Yufeng Chen
IPC分类号: C07D277/04
CPC分类号: C07D277/46 , C07C259/06 , C07C323/60
摘要: One aspect of the invention relates to isoform-selective HDAC inhibitors. Also provided are methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy. The invention also provides methods for treating cancer, methods for treating neurological diseases and methods for treating malaria. Additionally, the invention provides pharmaceutical compositions comprising an HDAC inhibitor of the invention; and kits comprising an HDAC inhibitor of the invention.
摘要翻译: 本发明的一个方面涉及同工型选择性HDAC抑制剂。 还提供了使癌细胞对放射治疗的细胞毒性作用敏感的方法。 本发明还提供了治疗癌症的方法,治疗神经疾病的方法和治疗疟疾的方法。 另外,本发明提供包含本发明的HDAC抑制剂的药物组合物; 和包含本发明的HDAC抑制剂的试剂盒。
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公开(公告)号:US20100196502A1
公开(公告)日:2010-08-05
申请号:US12375348
申请日:2007-08-02
申请人: Alan P. Kozikowski , Mira Jung , Anatoly Dritschilo , Arsen Gaysin , Pavel A. Petukhov , Werner Tueckmantel , Hongbin Yuan
发明人: Alan P. Kozikowski , Mira Jung , Anatoly Dritschilo , Arsen Gaysin , Pavel A. Petukhov , Werner Tueckmantel , Hongbin Yuan
IPC分类号: A61K31/426 , C07C237/00 , C07D277/20 , A61K31/16 , A61K31/4706 , A61K33/40 , A61K31/439 , A61K31/47 , A61K31/505 , A61K31/65 , A61K31/7052 , A61P33/06
CPC分类号: C07D277/46 , C07C259/06 , C07C323/60
摘要: One aspect of the invention relates to isoform-selective HDAC inhibitors. Also provided are methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy. The invention also provides methods for treating cancer, methods for treating neurological diseases and methods for treating malaria. Additionally, the invention provides pharmaceutical compositions comprising an HDAC inhibitor of the invention; and kits comprising a an HDAC inhibitor of the invention.
摘要翻译: 本发明的一个方面涉及同工型选择性HDAC抑制剂。 还提供了使癌细胞对放射治疗的细胞毒性作用敏感的方法。 本发明还提供了治疗癌症的方法,治疗神经疾病的方法和治疗疟疾的方法。 另外,本发明提供包含本发明的HDAC抑制剂的药物组合物; 和包含本发明的HDAC抑制剂的试剂盒。
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