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13 条记录 (耗时 0.027 秒)

    Delivery system for therapy comprising hollow seed, preferably polymeric
    8.
    发明申请
    Delivery system for therapy comprising hollow seed, preferably polymeric 审中-公开
    用于治疗的递送系统包括中空种子，优选聚合物

    公开(公告)号：US20060173443A1

    公开(公告)日：2006-08-03

    申请号：US11368443

    申请日：2006-03-07

    申请人： Anatoly Dritschilo ,  Mira Jung ,  Manny Subramanian

    发明人： Anatoly Dritschilo ,  Mira Jung ,  Manny Subramanian

    IPC分类号： A61K9/22

    CPC分类号： A61M37/0069

    摘要： Hollow metal and polymeric containers (or seeds) are provided having a therapeutic agent encapsulated therein, e.g., a nucleic acid or cytokine, that diffuses out of the seeds via one or more holes disposed therein and is thereby delivered to target sites, e.g., tumor cells. These hollow seeds can be precisely delivered to garget cites, e.g., within a tumor, preferably by use of stereotactic guidance, ultrasound, CT or MRI.

    摘要翻译： 提供空心金属和聚合物容器（或种子），其中包含一种治疗剂，例如核酸或细胞因子，其通过设置在其中的一个或多个孔扩散出种子，从而被递送到靶位点，例如肿瘤 细胞。 这些中空种子可以精确地递送到靶点，例如在肿瘤内，优选地通过使用立体定向指导，超声，CT或MRI。

    The p65 subunit of nf-kb for the radiosensitization of cells
    9.
    发明申请
    The p65 subunit of nf-kb for the radiosensitization of cells 审中-公开
    nf-kb的p65亚基用于细胞的放射增敏

    公开(公告)号：US20050287158A1

    公开(公告)日：2005-12-29

    申请号：US10504364

    申请日：2003-02-19

    申请人： Mira Jung ,  Anatoly Dritschilo

    发明人： Mira Jung ,  Anatoly Dritschilo

    IPC分类号： A61K38/00 ,  A61K38/17 ,  A61K38/18 ,  A61K39/00 ,  A61K41/00 ,  C07K14/47

    CPC分类号： A61K38/1709 ,  A61K41/0038 ,  C07K14/4702

    摘要： The transcription factor NF-κB is activated in response to various stimuli including ionizing radiation. Disruption of NFκB activation by mutant forms of the NF-κB inhibitor IκB-α or by proteasome inhibitors enhances both sensitivity to radiation and radiation-induced apoptasis. The present invention shows that expression of a dominant negative fragment of human p65 (p65DN) leads to down-regulation of both endogenous p65 protein and its mRNA. The dominant negative protein also inhibits radiation-induced NF-κB activation by preventing the proteolysis of IκB-α, resulting in enhancement of cellular radiosensitivity and radiation-induced apoptosis. The region of p65 in the dominant negative fragment is thus a molecular target for disruption of NF-κB activation and sensitization of tumors to radiotherapy.

    摘要翻译： 转录因子NF-κB被响应于包括电离辐射的各种刺激而被激活。 通过NF-κB抑制剂IkappaB-α或蛋白酶体抑制剂的突变形式破坏NFkappaB激活增强了对放射和辐射诱导的凋亡的敏感性。 本发明显示人p65（p65DN）的显性负片段的表达导致内源性p65蛋白及其mRNA的下调。 显性阴性蛋白质还通过阻止IkappaB-α的蛋白水解来抑制放射诱导的NF-κB活化，导致细胞放射敏感性增加和放射诱导的细胞凋亡。 因此，显性负片段中p65的区域是用于破坏NF-κB活化和肿瘤对放射治疗敏化的分子靶标。