发明授权
- 专利标题： Soluble recombinant influenza antigens
- 专利标题（中）： 可溶性重组流感抗原
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申请号： US13001111申请日： 2009-07-07
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公开(公告)号： US08771703B2公开(公告)日： 2014-07-08
- 发明人: Manon Couture , Nathalie Landry , Louis-Philippe Vezina , Michéle Dargis
- 申请人： Manon Couture , Nathalie Landry , Louis-Philippe Vezina , Michéle Dargis
- 申请人地址： CA Quebec
- 专利权人： Medicago Inc.
- 当前专利权人： Medicago Inc.
- 当前专利权人地址： CA Quebec
- 代理机构： King & Spalding LLP
- 代理商 Kenneth H. Sonnenfeld
- 国际申请： PCT/CA2009/000941 WO 20090707
- 国际公布： WO2010/003235 WO 20100114
- 主分类号： A61K39/145
- IPC分类号： A61K39/145 ; A61K39/00 ; C12N15/82 ; C12N15/79 ; C12N15/84 ; C12N15/44 ; C12N15/62 ; C12N15/90 ; C12N5/10 ; C07K14/005
摘要：
The present invention provides a recombinant soluble trimeric hemagglutinin (rHA) protein comprising a hemagglutinin ectodomain and an oligomerization domain. The rHA is produced as a soluble homotrimer, and may further comprises a signal peptide and/or an endoplasmic reticulum (ER) retention signal. The invention is also directed to nucleic acids encoding the rHA of the invention, as well as vectors and chimeric constructs comprising the nucleic acid. Methods of producing the rHA are also provided. The rHA described herein may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
公开/授权文献
- US20110104753A1 Soluble Recombinant Influenza Antigens 公开/授权日：2011-05-05