发明授权
- 专利标题： Cell-penetrating peptides
- 专利标题（中）： 细胞穿透肽
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申请号： US13321176申请日： 2010-05-19
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公开(公告)号： US08772449B2公开(公告)日： 2014-07-08
- 发明人: Mariko Morishita , Kozo Takayama , Reiji Nishio , Nobuo Ida
- 申请人： Mariko Morishita , Kozo Takayama , Reiji Nishio , Nobuo Ida
- 申请人地址： JP Tokyo
- 专利权人： Toray Industries, Inc.
- 当前专利权人： Toray Industries, Inc.
- 当前专利权人地址： JP Tokyo
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 优先权： JP2009-122096 20090520; JP2010-071774 20100326
- 国际申请： PCT/JP2010/058420 WO 20100519
- 国际公布： WO2010/134537 WO 20101125
- 主分类号： C07K7/08
- IPC分类号： C07K7/08 ; A61K38/10 ; C07K14/435 ; A61K9/00
摘要：
A cell-penetrating peptide of (A) to (D) below gives cell membrane permeability and transmucosal absorbability to a physiologically active substance: (A) a peptide having the amino acid sequence of SEQ ID NO:1; (B) a peptide represented by SEQ ID NO:1 except that one or several basic amino acids are changed; (C) a peptide represented by SEQ ID NO:1 except that 1 to 5 amino acids are changed; (D) a peptide having: the reverse sequence of any of (A) to (C); an amino acid sequence which is the same as the reverse sequence of (A) except that one or several basic amino acids are changed; or an amino acid sequence which is the same as the reverse sequence of (A) except that 1 to 5 amino acids are changed.
公开/授权文献
- US20120065124A1 CELL-PENETRATING PEPTIDES 公开/授权日：2012-03-15
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