发明授权
US08785392B2 Method for inhibiting cancer metastasis by administration of the extracellular domain DLK1 or a DLK1-FC fusion protein
有权
通过施用细胞外结构域DLK1或DLK1-FC融合蛋白抑制癌症转移的方法
- 专利标题： Method for inhibiting cancer metastasis by administration of the extracellular domain DLK1 or a DLK1-FC fusion protein
- 专利标题（中）： 通过施用细胞外结构域DLK1或DLK1-FC融合蛋白抑制癌症转移的方法
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申请号： US13142818申请日： 2010-04-13
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公开(公告)号： US08785392B2公开(公告)日： 2014-07-22
- 发明人: Young Woo Park , Kiwon Jo , Donghee Lee , Jung Yu , Ji Hyun Park , Chan-Woong Park , Eun Jin Kim , Yun Jung Park
- 申请人： Young Woo Park , Kiwon Jo , Donghee Lee , Jung Yu , Ji Hyun Park , Chan-Woong Park , Eun Jin Kim , Yun Jung Park
- 申请人地址： KR Daejeon
- 专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人地址： KR Daejeon
- 代理机构： Lando & Anastasi LLP
- 优先权： KR10-2010-0023180 20100316
- 国际申请： PCT/KR2010/002277 WO 20100413
- 国际公布： WO2011/115323 WO 20110922
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61K38/17 ; A61K39/00 ; C07K14/435 ; C07K14/705 ; C07K14/735 ; C07K16/28 ; C07K16/00 ; C07K14/475
摘要：
A recombinant expression vector, comprising extracellular soluble domain genes of DLK1 and IgG antibody Fc domain genes, is constructed, and DLK1-Fc fusion protein is expressed and purified at 293E cell. The invention confirmed the efficacy as a drug for inhibiting cancer metastasis by confirming markedly reduced migration of cancer cells by DLK1-Fc fusion protein and also computing pharmacokinetic parameters. DLK1-Fc fusion protein has relatively higher stability than non-fusion protein, significantly reduces migration of various cancer cell lines, and provides superior cancer metastasis inhibition effect even at small concentration. Accordingly, DLK1-Fc fusion protein can be used efficaciously as an effective ingredient of a composition for inhibiting cancer metastasis.
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