A system for calibrating a response to an exhaust-stream NOx level in a motor vehicle is provided. The system comprises a NOx sensor that includes an electrode, a current from the electrode responsive to the exhaust-stream NOx level while a bias voltage is applied to the electrode. The system further comprises a controller configured to interrupt the bias voltage and to adjust a motor-vehicle response to the current based at least partly on an attained voltage of the electrode while the bias voltage is interrupted. Other embodiments provide a method of calibrating a NOx sensor response in terms of gain and offset parameters.