发明授权
- 专利标题： Medical implants and methods of making medical implants
- 专利标题（中）： 医疗植入物和制造医疗植入物的方法
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申请号： US12648106申请日： 2009-12-28
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公开(公告)号： US08834913B2公开(公告)日： 2014-09-16
- 发明人: Wendy J. Shaw , Clement R. Yonker , John L. Fulton , Barbara J. Tarasevich , James B. McClain , Doug Taylor
- 申请人： Wendy J. Shaw , Clement R. Yonker , John L. Fulton , Barbara J. Tarasevich , James B. McClain , Doug Taylor
- 申请人地址： US WA Richland
- 专利权人： Battelle Memorial Institute
- 当前专利权人： Battelle Memorial Institute
- 当前专利权人地址： US WA Richland
- 代理机构： Wilson, Sonsini, Goodrich & Rosati
- 主分类号： A61F2/00
- IPC分类号： A61F2/00 ; A61K31/727
摘要：
A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.
公开/授权文献
- US20110159069A1 Medical Implants and Methods of Making Medical Implants 公开/授权日：2011-06-30
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