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公开(公告)号：US11369498B2
公开(公告)日：2022-06-28
申请号：US13014632
申请日：2011-01-26
申请人： James B. McClain , Douglas Taylor , David Enscore
发明人： James B. McClain , Douglas Taylor , David Enscore
摘要： Stent delivery systems having improved deliverability comprising an elongate member having an inflation lumen and a guidewire lumen therein; a balloon having an interior that is in fluid communication with the inflation lumen; and a stent comprising a coating mounted on the balloon. Methods for making stent delivery systems having improved deliverability. Methods for delivering two stent delivery systems concurrently through a guiding catheter, each stent delivery system comprising elongate member having an inflation lumen and a guidewire lumen therein, a balloon having an interior that is in fluid communication with the inflation lumen, and a stent comprising a coating mounted on the balloon. Stent coatings may comprise a pharmaceutical agent at least a portion of which is in crystalline form.
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公开(公告)号：US09789233B2
公开(公告)日：2017-10-17
申请号：US12426198
申请日：2009-04-17
申请人： James B. McClain , Douglas Taylor
发明人： James B. McClain , Douglas Taylor
CPC分类号： A61L31/148 , A61F2/91 , A61F2210/0004 , A61F2250/0035 , A61F2250/0067 , A61L31/16 , A61L2300/216 , A61L2300/604 , A61L2300/606 , A61L2300/608 , A61L2300/63 , A61L2420/08
摘要： Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
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公开(公告)号：US09510856B2
公开(公告)日：2016-12-06
申请号：US13384216
申请日：2010-07-16
IPC分类号： A61M31/00 , A61M37/00 , A61B17/20 , A61B17/3207 , A61L29/08 , A61L29/16 , A61B17/00 , A61B17/22 , A61M25/10
CPC分类号： A61M25/10 , A61B17/320725 , A61B2017/00893 , A61B2017/22051 , A61B2017/22061 , A61B2017/22065 , A61L29/085 , A61L29/16 , A61L2300/416 , A61L2300/606 , A61M2025/105
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.
摘要翻译： 提供一种涂覆的可植入医疗装置，包括：基底; 以及涂层，其设置在所述基底上，其中所述涂层包含至少一种聚合物和至少一种治疗期望形态的药剂和/或至少一种活性生物剂和任选的一种或多种药物载体; 其中基本上所有的药剂和/或活性生物制剂都保留在涂层内和衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将医疗装置部署在受试者的身体中时 一部分药剂和/或活性生物剂在干预部位与至少一部分聚合物和/或药物载体的至少一部分一起递送。
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公开(公告)号：US08834913B2
公开(公告)日：2014-09-16
申请号：US12648106
申请日：2009-12-28
申请人： Wendy J. Shaw , Clement R. Yonker , John L. Fulton , Barbara J. Tarasevich , James B. McClain , Doug Taylor
发明人： Wendy J. Shaw , Clement R. Yonker , John L. Fulton , Barbara J. Tarasevich , James B. McClain , Doug Taylor
IPC分类号： A61F2/00 , A61K31/727
CPC分类号： A61L31/10 , A61K31/727 , A61L31/16 , A61L2300/42 , A61L2400/18
摘要： A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.
摘要翻译： 一种具有氧化表面的基底和与氧化表面共价结合的硅烷衍生物涂层的医用植入装置。 生物活性剂与硅烷衍生物涂层共价键合。 一种可植入支架装置，其包括具有氧化表面的支架芯，其具有与其共价键合的硅烷衍生物层。 包含聚乙二醇（PEG）的间隔层与硅烷衍生物层共价键合，蛋白质与PEG共价键合。 一种制造医疗植入装置的方法，包括提供具有表面的基底，氧化表面并与衍生的硅烷反应以形成共价键合到该表面的硅烷涂层。 然后将生物活性剂共价键合到硅烷涂层。 在特定情况下，生物吸收性聚合物和/或药剂的附加涂层沉积在生物活性剂上。
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公开(公告)号：US20120323311A1
公开(公告)日：2012-12-20
申请号：US13445723
申请日：2012-04-12
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/63
摘要： Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
摘要翻译： 本文提供的装置包括：a。 支架; b。 在所述支架框架上的多个层以形成所述装置; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。
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公开(公告)号：US07141496B2
公开(公告)日：2006-11-28
申请号：US10762905
申请日：2004-01-22
申请人： James P. DeYoung , James B. McClain , Stephen M. Gross , Doug Taylor , Mark I. Wagner , David Brainard
发明人： James P. DeYoung , James B. McClain , Stephen M. Gross , Doug Taylor , Mark I. Wagner , David Brainard
IPC分类号： H01L21/44
CPC分类号： H01L21/32051 , H01L21/283 , H01L21/288 , H01L21/76814 , H01L21/76843 , H01L21/76871
摘要： A method of treating a dielectric surface portion of a semiconductor substrate, comprising the steps of: (a) providing a semiconductor substrate having a dielectric surface portion; and then (b) treating said dielectric surface portion with a coating reagent, the coating reagent comprising a reactive group coupled to a coordinating group, with the coordinating group having a metal bound thereto, so that the metal is deposited on the dielectric surface portion to produce a surface portion treated with a metal.
摘要翻译： 一种处理半导体衬底的电介质表面部分的方法，包括以下步骤：（a）提供具有电介质表面部分的半导体衬底; 然后（b）用涂层试剂处理所述电介质表面部分，所述涂覆试剂包含与配位基团偶联的反应基团，所述配位基团与其结合金属，使得金属沉积在电介质表面部分上 产生用金属处理的表面部分。
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公开(公告)号：US06919167B2
公开(公告)日：2005-07-19
申请号：US10294222
申请日：2002-11-14
申请人： James DeYoung , James B. McClain
发明人： James DeYoung , James B. McClain
IPC分类号： G03F20060101 , G03F7/00 , G03F7/32 , G03F7/36
摘要： A method for carrying out positive tone lithography with a carbon dioxide solvent system is carried out by (a) providing a substrate having a polymer resist layer formed thereon; (b) exposing at least one portion of the polymer resist layer to radiant energy to form at least one light field region in the polymer resist layer; and then (c) contacting the polymer resist layer to a carbon dioxide solvent system, the solvent system preferably comprising a polar group, under conditions in which the at least one light field region is preferentially removed.
摘要翻译： 通过（a）提供其上形成有聚合物抗蚀剂层的基材，进行用二氧化碳溶剂系统进行正色调光刻的方法; （b）将聚合物抗蚀剂层的至少一部分暴露于辐射能以在聚合物抗蚀剂层中形成至少一个光场区域; 然后（c）在其中优选除去所述至少一个光场区域的条件下，使所述聚合物抗蚀剂层与二氧化碳溶剂体系接触，所述溶剂体系优选包含极性基团。
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8.发明授权Methods for transferring supercritical fluids in microelectronic and other industrial processes 失效在微电子和其他工业过程中转移超临界流体的方法公开(公告)号：US06905555B2
公开(公告)日：2005-06-14
申请号：US10448474
申请日：2003-05-30
CPC分类号： B08B7/0021 , B05D1/18 , B05D2401/90 , H01L21/02063 , H01L21/02101 , H01L21/67017 , H01L21/67028 , Y10T137/0324
摘要： A method of displacing a supercritical fluid from a pressure vessel (e.g., in a microelectronic manufacturing process), with the steps of: providing an enclosed pressure vessel containing a first supercritical fluid (said supercritical fluid preferably comprising carbon dioxide); adding a second fluid (typically also a supercritical fluid) to said vessel, with said second fluid being added at a pressure greater than the pressure of the first supercritical fluid, and with said second fluid having a density less than that of the first supercritical fluid; forming an interface between the first supercritical fluid and the second fluid; and displacing at least a portion of the first supercritical fluid from the vessel with the pressure of the second, preferably fluid while maintaining the interface therebetween.
摘要翻译： 一种从压力容器（例如，在微电子制造过程中）置换超临界流体的方法，其步骤包括：提供包含第一超临界流体（所述超临界流体优选包含二氧化碳）的封闭压力容器; 向所述容器中加入第二流体（通常也是超临界流体），其中所述第二流体以大于第一超临界流体的压力的压力加入，并且所述第二流体的密度小于第一超临界流体的密度 ; 在所述第一超临界流体和所述第二流体之间形成界面; 并且使第二超临界流体的至少一部分与第二流体（优选流体）的压力从容器移位，同时保持其间的界面。
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公开(公告)号：US06711773B2
公开(公告)日：2004-03-30
申请号：US10234766
申请日：2002-09-04
IPC分类号： D06B2320
CPC分类号： D06F43/005 , B08B7/0021 , D06F43/007 , D06F43/08
摘要： A system for the controlled addition of detergent formulations and the like to a carbon dioxide cleaning apparatus comprises: (a) a high pressure wash vessel; (b) an auxiliary vessel; (c) a drain line connecting the auxiliary vessel to the wash vessel; (d) optionally but preferably, a separate vent line connecting the auxiliary vessel to the wash vessel; (e) a detergent reservoir; and (f) a detergent supply line connecting the detergent reservoir to the auxiliary vessel. An advantage of this apparatus is that, because the detergent formulation can be pumped into the auxiliary vessel in a predetermined aliquot or amount, which predetermined aliquot or amount can then be transferred into the wash vessel where it combines with the liquid carbon dioxide cleaning solution, the detergent formulation can be added to the cleaning solution in a more controlled or accurate manner. An alternate embodiment adapted for the addition of aqueous detergent formulations and the like to a carbon dioxide dry cleaning system under turbulent conditions comprises: (a) a high pressure wash vessel; (b) a filter; (c) a carbon dioxide cleaning solution drain line interconnecting the wash vessel to the filter; (d) a carbon dioxide cleaning solution supply line connecting the filter to the wash vessel; (e) a first high pressure pump (i.e., a pump that is capable of pumping liquid solutions comprising liquid carbon dioxide) operably connected to the drain line; (f) a detergent formulation reservoir; (g) a detergent formulation supply line connecting the reservoir to the carbon dioxide cleaning solution supply line; and (h) a second high pressure pump operably connected to the detergent formulation supply line for transferring detergent formulation from the detergent formulation reservoir into the carbon dioxide cleaning solution under turbulent conditions.
摘要翻译： 用于将二氧化碳清洗装置中洗涤剂配方等控制加入的系统包括：（a）高压洗涤容器; （b）辅助船只; （c）将辅助容器连接到洗涤容器的排水管线; （d）可选地，但优选地，将辅助容器连接到洗涤容器的单独排放管线; （e）洗涤剂储存器; 和（f）将洗涤剂储存器连接到辅助容器的洗涤剂供应管线。 该设备的优点在于，由于洗涤剂配方可以以预定的等分试样或数量泵送到辅助容器中，该预定的等分试样或数量可随后被转移到与液体二氧化碳清洗溶液结合的洗涤容器中， 洗涤剂配方可以以更受控制或更准确的方式添加到清洁溶液中。 适于在湍流条件下将含水洗涤剂配方等添加到二氧化碳干洗系统的替代实施方案包括：（a）高压洗涤容器; （b）过滤器; （c）将洗涤容器与过滤器相互连接的二氧化碳清洗液排出管线; （d）将过滤器连接到洗涤容器的二氧化碳清洗溶液供应管线; （e）可操作地连接到排出管线的第一高压泵（即，能够泵送包含液体二氧化碳的液体溶液的泵）; （f）洗涤剂配制容器; （g）将储存器连接到二氧化碳清洗溶液供应管线的洗涤剂配制剂供应管线; 和（h）第二高压泵，其可操作地连接到洗涤剂配方供应管线，用于将洗涤剂配方从紊乱的条件下将洗涤剂配制剂从洗涤剂配制容器转移到二氧化碳清洗溶液中。
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公开(公告)号：US06613157B2
公开(公告)日：2003-09-02
申请号：US09951092
申请日：2001-09-13
IPC分类号： B08B300
CPC分类号： B08B7/0021 , C23G5/00 , H01L21/02063 , Y10S134/902 , Y10S438/906
摘要： A method of cleaning and removing solid particles during a manufacturing process from a microelectronic device such as a resist-coated semiconductor substrate, a MEM's device, or an optoelectronic device comprising the steps of: (a) providing a partially fabricated integrated circuit, MEM's device, or optoelectronic device having water and entrained solutes on the substrate; (b) providing a densified (e.g., liquid or supercritical) carbon dioxide cleaning composition, the cleaning composition comprising carbon dioxide and a cleaning adjunct, the cleaning adjunct selected from the group consisting of cosolvents, surfactants, and combinations thereof; (c) immersing the surface portion in the densified carbon dioxide cleaning composition to remove solid particles from the surface portion; and then (d) removing the cleaning composition from the surface portion. Process parameters are controlled so that the cleaning composition is maintained as a homogeneous composition during the immersing step, the removing step, or both the immersing and removing step, without substantial deposition of the drying/cleaning adjunct or solid particles on the substrate.
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