公开(公告)号：US08834913B2

公开(公告)日：2014-09-16

申请号：US12648106

申请日：2009-12-28

申请人： Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

发明人： Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

IPC分类号： A61F2/00 ,  A61K31/727

CPC分类号： A61L31/10 ,  A61K31/727 ,  A61L31/16 ,  A61L2300/42 ,  A61L2400/18

摘要： A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.

摘要翻译： 一种具有氧化表面的基底和与氧化表面共价结合的硅烷衍生物涂层的医用植入装置。 生物活性剂与硅烷衍生物涂层共价键合。 一种可植入支架装置，其包括具有氧化表面的支架芯，其具有与其共价键合的硅烷衍生物层。 包含聚乙二醇（PEG）的间隔层与硅烷衍生物层共价键合，蛋白质与PEG共价键合。 一种制造医疗植入装置的方法，包括提供具有表面的基底，氧化表面并与衍生的硅烷反应以形成共价键合到该表面的硅烷涂层。 然后将生物活性剂共价键合到硅烷涂层。 在特定情况下，生物吸收性聚合物和/或药剂的附加涂层沉积在生物活性剂上。

公开(公告)号：US20110159069A1

公开(公告)日：2011-06-30

申请号：US12648106

申请日：2009-12-28

申请人： Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

发明人： Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

IPC分类号： A61F2/02 ,  A61K31/727 ,  A61K38/16 ,  A61F11/00 ,  A61P43/00

CPC分类号： A61L31/10 ,  A61K31/727 ,  A61L31/16 ,  A61L2300/42 ,  A61L2400/18

摘要： A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.

摘要翻译： 一种具有氧化表面的基底和与氧化表面共价结合的硅烷衍生物涂层的医用植入装置。 生物活性剂与硅烷衍生物涂层共价键合。 一种可植入支架装置，其包括具有氧化表面的支架芯，其具有与其共价键合的硅烷衍生物层。 包含聚乙二醇（PEG）的间隔层与硅烷衍生物层共价键合，蛋白质与PEG共价键合。 一种制造医疗植入装置的方法，包括提供具有表面的基底，氧化表面并与衍生的硅烷反应以形成共价键合到该表面的硅烷涂层。 然后将生物活性剂共价键合到硅烷涂层。 在特定情况下，生物吸收性聚合物和/或药剂的附加涂层沉积在生物活性剂上。

公开(公告)号：US09539593B2

公开(公告)日：2017-01-10

申请号：US11877591

申请日：2007-10-23

申请人： James B. McClain ,  Doug Taylor ,  Ed Dickinson ,  Steve Worm

发明人： James B. McClain ,  Doug Taylor ,  Ed Dickinson ,  Steve Worm

IPC分类号： B05C13/02 ,  B05B5/053 ,  A61L31/10 ,  B05B5/08

CPC分类号： B05B5/0533 ,  A61L31/10 ,  B05B5/082 ,  B05B13/0207 ,  B05C13/025

摘要： A stent holder for mounting and electrically charging a stent during coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. An assembly for supporting and electrically charging a stent during the coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A chamber for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A method for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles comprising inert polymers, pharmaceutical or biological agents is provided.

摘要翻译： 提供一种用于在使用干燥颗粒涂覆支架期间安装和充电支架的支架支架，所述颗粒包括惰性聚合物，药物或生物制剂。 提供了一种用于在使用干燥颗粒涂覆支架期间支撑和充电支架的组件，所述颗粒包含惰性聚合物，药物或生物制剂。 提供了一种用于在支架周围产生电场并用于支撑，充电并将支架暴露于干颗粒的腔室，包括惰性聚合物，药物或生物制剂的颗粒。 提供了一种用于在支架周围产生电场并用于支撑，充电和将支架暴露于包含惰性聚合物，药物或生物制剂的干燥颗粒的方法。

公开(公告)号：US07141496B2

公开(公告)日：2006-11-28

申请号：US10762905

申请日：2004-01-22

申请人： James P. DeYoung ,  James B. McClain ,  Stephen M. Gross ,  Doug Taylor ,  Mark I. Wagner ,  David Brainard

发明人： James P. DeYoung ,  James B. McClain ,  Stephen M. Gross ,  Doug Taylor ,  Mark I. Wagner ,  David Brainard

IPC分类号： H01L21/44

CPC分类号： H01L21/32051 ,  H01L21/283 ,  H01L21/288 ,  H01L21/76814 ,  H01L21/76843 ,  H01L21/76871

摘要： A method of treating a dielectric surface portion of a semiconductor substrate, comprising the steps of: (a) providing a semiconductor substrate having a dielectric surface portion; and then (b) treating said dielectric surface portion with a coating reagent, the coating reagent comprising a reactive group coupled to a coordinating group, with the coordinating group having a metal bound thereto, so that the metal is deposited on the dielectric surface portion to produce a surface portion treated with a metal.

摘要翻译： 一种处理半导体衬底的电介质表面部分的方法，包括以下步骤：（a）提供具有电介质表面部分的半导体衬底; 然后（b）用涂层试剂处理所述电介质表面部分，所述涂覆试剂包含与配位基团偶联的反应基团，所述配位基团与其结合金属，使得金属沉积在电介质表面部分上 产生用金属处理的表面部分。

公开(公告)号：US20100063580A1

公开(公告)日：2010-03-11

申请号：US12522379

申请日：2008-01-08

申请人： James B. McClain ,  Doug Taylor ,  Robert Rabiner

发明人： James B. McClain ,  Doug Taylor ,  Robert Rabiner

IPC分类号： A61F2/92 ,  B05D1/36

CPC分类号： A61L31/10 ,  A61F2/91 ,  A61L31/148

摘要： A method for preparing a laminate coronary stent comprising: providing a stent framework; and depositing a plurality of layers on said stent framework to form said laminate coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer.

摘要翻译： 一种制备层压冠状支架的方法，包括：提供支架框架; 以及在所述支架框架上沉积多个层以形成所述层压冠状支架; 其中所述层中的至少一个包含生物可吸收聚合物。

公开(公告)号：US06989172B2

公开(公告)日：2006-01-24

申请号：US10681515

申请日：2003-10-08

申请人： James P. DeYoung ,  James B. McClain ,  Stephen M. Gross ,  Doug Taylor ,  Mark I. Wagner ,  David Brainard

发明人： James P. DeYoung ,  James B. McClain ,  Stephen M. Gross ,  Doug Taylor ,  Mark I. Wagner ,  David Brainard

IPC分类号： B05D5/12 ,  B05D1/18

CPC分类号： H01L21/283 ,  B05D1/18 ,  B05D2401/90 ,  H01L21/28556 ,  H01L21/288 ,  H01L21/67028 ,  H01L28/65

摘要： A method of coating a substrate comprises the steps of: (a) providing a substrate in an enclosed vessel, the substrate having a surface portion; (b) at least partially filling the enclosed vessel with a first supercritical fluid so that said first supercritical fluid contacts the surface portion, with the first supercritical fluid carrying or containing a coating component; then (c) adding a separate compressed gas atmosphere to the reaction vessel so that a boundary is formed between the first supercritical fluid and the separate compressed gas atmosphere, said separate compressed gas atmosphere having a density less than said first supercritical fluid; and then (d) displacing said first supercritical fluid from said vessel by continuing adding said separate compressed gas atmosphere to said vessel so that said boundary moves across said surface portion and a thin film of coating component is deposited on said microelectronic substrate.

公开(公告)号：US20080095919A1

公开(公告)日：2008-04-24

申请号：US11877591

申请日：2007-10-23

申请人： James B. McClain ,  Doug Taylor ,  Ed Dicklnson ,  Steve Worm

发明人： James B. McClain ,  Doug Taylor ,  Ed Dicklnson ,  Steve Worm

IPC分类号： A61L33/00 ,  B05B5/025

CPC分类号： B05B5/0533 ,  A61L31/10 ,  B05B5/082 ,  B05B13/0207 ,  B05C13/025

摘要： A stent holder for mounting and electrically charging a stent during coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. An assembly for supporting and electrically charging a stent during the coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A chamber for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A method for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles comprising inert polymers, pharmaceutical or biological agents is provided.

摘要翻译： 提供一种用于在使用干燥颗粒涂覆支架期间安装和充电支架的支架支架，所述颗粒包括惰性聚合物，药物或生物制剂。 提供了一种用于在使用干燥颗粒涂覆支架期间支撑和充电支架的组件，所述颗粒包含惰性聚合物，药物或生物制剂。 提供了一种用于在支架周围产生电场并用于支撑，充电并将支架暴露于干颗粒的腔室，包括惰性聚合物，药物或生物制剂的颗粒。 提供了一种用于在支架周围产生电场并用于支撑，充电和将支架暴露于包含惰性聚合物，药物或生物制剂的干燥颗粒的方法。

公开(公告)号：US07592035B2

公开(公告)日：2009-09-22

申请号：US11261299

申请日：2005-10-28

申请人： James P. DeYoung ,  James B. McClain ,  Stephen M. Gross ,  Doug Taylor ,  Mark I. Wagner ,  David Brainard

发明人： James P. DeYoung ,  James B. McClain ,  Stephen M. Gross ,  Doug Taylor ,  Mark I. Wagner ,  David Brainard

IPC分类号： B05D5/12

CPC分类号： H01L21/283 ,  B05D1/18 ,  B05D2401/90 ,  H01L21/28556 ,  H01L21/288 ,  H01L21/67028 ,  H01L28/65

摘要： A method of coating a substrate comprises the steps of: (a) providing a substrate in an enclosed vessel, the substrate having a surface portion; (b) at least partially filling the enclosed vessel with a first supercritical fluid so that said first supercritical fluid contacts the surface portion, with the first supercritical fluid carrying or containing a coating component; then (c) adding a separate compressed gas atmosphere to the reaction vessel so that a boundary is formed between the first supercritical fluid and the separate compressed gas atmosphere, said separate compressed gas atmosphere having a density less than said first supercritical fluid; and then (d) displacing said first supercritical fluid from said vessel by continuing adding said separate compressed gas atmosphere to said vessel so that said boundary moves across said surface portion and a thin film of coating component is deposited on said microelectronic substrate.

摘要翻译： 涂覆基材的方法包括以下步骤：（a）在封闭容器中提供基材，所述基材具有表面部分; （b）用第一超临界流体至少部分地填充封闭的容器，使得所述第一超临界流体接触表面部分，第一超临界流体携带或包含涂层组分; 然后（c）向所述反应容器中加入单独的压缩气体气氛，使得在所述第一超临界流体和所述单独的压缩气体气氛之间形成边界，所述单独的压缩气体气氛的密度小于所述第一超临界流体; 然后（d）通过将所述单独的压缩气体气氛继续加入到所述容器中，使所述边界移动穿过所述表面部分并且将涂层组分的薄膜沉积在所述微电子衬底上，从而使所述第一超临界流体从所述容器移位。

公开(公告)号：US20090123515A1

公开(公告)日：2009-05-14

申请号：US11995687

申请日：2006-07-14

申请人： Doug Taylor ,  Jim McClain ,  Clint Smoke ,  Mike Cole ,  James DeYoung

发明人： Doug Taylor ,  Jim McClain ,  Clint Smoke ,  Mike Cole ,  James DeYoung

IPC分类号： A61F2/00 ,  A61K31/436 ,  B05D7/02

CPC分类号： A61F2/82 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/606 ,  A61L2300/63 ,  A61L2420/08 ,  Y10T428/264 ,  Y10T428/265 ,  Y10T428/31507 ,  Y10T428/31544 ,  Y10T428/31551 ,  Y10T428/31663 ,  Y10T428/31786 ,  Y10T428/31935 ,  Y10T428/31938

摘要： A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.

摘要翻译： 一种用于在基底上沉积包含聚合物和药剂的涂层的方法，包括以下步骤：通过第一孔排出至少一种治疗上需要的干粉形式的药剂; 通过第二孔排出至少一种干粉形式的聚合物; 将所述聚合物和/或药物颗粒沉积到所述基底上，其中在所述基底和所述药物和/或聚合物颗粒之间保持电位，从而形成所述涂层; 并且在基本上不改变所述药剂的形态的条件下烧结所述涂层。

公开(公告)号：US20050262240A1

公开(公告)日：2005-11-24

申请号：US11136086

申请日：2005-05-24

申请人： Timothy Drees ,  Stella Zimmerman ,  Doug Taylor ,  Lenny Rachitsky

发明人： Timothy Drees ,  Stella Zimmerman ,  Doug Taylor ,  Lenny Rachitsky

IPC分类号： G06F15/16 ,  G06F15/173 ,  H04L12/26

CPC分类号： G06F11/3452 ,  G06F11/3476 ,  G06F11/3495 ,  G06F17/3089 ,  G06F2201/86 ,  H04L43/0817

摘要： A system and method for visually and mathematically correlating website performance datasets with analytics datasets and optionally with back end application performance datasets in order to determine if variations in one dataset are caused by or related to variations in another dataset and simultaneously determines the cost of slow or unavailable websites by comparing expected traffic to actual traffic during the slow or errant period.

摘要翻译： 用于将网站性能数据集与分析数据集以及可选地与后端应用性能数据集视觉和数学相关的系统和方法，以便确定一个数据集中的变化是由另一数据集的变化引起的还是与其他数据集的变化相关，并同时确定慢速或 通过将预期流量与实际流量进行比较，在缓慢或错误的期间内不可用的网站。