Invention Grant
US08846032B2 MDCK cell lines supporting viral growth to high titers and bioreactor process using the same
有权
支持病毒生长至高滴度的MDCK细胞系和使用其的生物反应器过程
- Patent Title: MDCK cell lines supporting viral growth to high titers and bioreactor process using the same
- Patent Title (中): 支持病毒生长至高滴度的MDCK细胞系和使用其的生物反应器过程
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Application No.: US13595897Application Date: 2012-08-27
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Publication No.: US08846032B2Publication Date: 2014-09-30
- Inventor: Jonathan Liu , Richard Schwartz , Mark Thompson , Luis Maranga , Mridul Ghosh , Ajit Subramanian , Simon Sheng-Tsiung Hsu
- Applicant: Jonathan Liu , Richard Schwartz , Mark Thompson , Luis Maranga , Mridul Ghosh , Ajit Subramanian , Simon Sheng-Tsiung Hsu
- Applicant Address: US MD Gaithersburg
- Assignee: MedImmune, LLC
- Current Assignee: MedImmune, LLC
- Current Assignee Address: US MD Gaithersburg
- Agency: Grant IP, Inc.
- Main IPC: A61K39/145
- IPC: A61K39/145 ; A01N65/00 ; A61K39/00 ; C12N5/02 ; C07K17/00 ; C12N7/00
Abstract:
The present invention relates to novel MDCK cells which can be to grow viruses, e.g., influenza viruses, in cell culture to higher titer than previously possible. The MDCK cells can be adapted to serum-free culture medium. The present invention further relates to cell culture compositions comprising the MDCK cells and cultivation methods for growing the MDCK cells. The present invention further relates to methods for producing influenza viruses in cell culture using the MDCK cells of the invention.
Public/Granted literature
- US20130052717A1 MDCK CELL LINES SUPPORTING VIRAL GROWTH TO HIGH TITERS AND BIOREACTOR PROCESS USING THE SAME Public/Granted day:2013-02-28
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