Invention Grant
US08853199B2 Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
有权
羟基化和甲氧基化的嘧啶基环戊烷作为AKT蛋白激酶抑制剂
- Patent Title: Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
- Patent Title (中): 羟基化和甲氧基化的嘧啶基环戊烷作为AKT蛋白激酶抑制剂
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Application No.: US13272079Application Date: 2011-10-12
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Publication No.: US08853199B2Publication Date: 2014-10-07
- Inventor: Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik , Eli M. Wallace , Stephen T. Schlachter , Anna L. Banka , Jun Liang , Brian Safina , Birong Zhang , Christine Chabot , Steven Do
- Applicant: Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik , Eli M. Wallace , Stephen T. Schlachter , Anna L. Banka , Jun Liang , Brian Safina , Birong Zhang , Christine Chabot , Steven Do
- Applicant Address: US CO Boulder US CA South San Francisco
- Assignee: Array Biopharma, Inc.,Genentech, Inc.
- Current Assignee: Array Biopharma, Inc.,Genentech, Inc.
- Current Assignee Address: US CO Boulder US CA South San Francisco
- Agency: Viksnins, Harris & Padys PLLP
- Main IPC: C07D409/12
- IPC: C07D409/12 ; C07D409/14 ; C07D403/12 ; C07D401/12 ; C07D405/12 ; C07D413/12 ; A61K31/496 ; A61P35/00 ; A61P29/00 ; A61P25/28 ; C07D239/70
Abstract:
The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Public/Granted literature
- US20120232055A1 HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS Public/Granted day:2012-09-13
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