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发明授权
US08865648B2 Monomeric and dimeric forms of adiponectin receptor fragments and methods of use 有权
脂联素受体片段的单体和二聚体形式和使用方法

Monomeric and dimeric forms of adiponectin receptor fragments and methods of use
摘要：
Methods are disclosed for determining progression of a condition, onset of a condition, or efficacy of treatment of a condition characterized by an adipocyte imbalance in a patient. In addition, methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using monomeric, homodimeric, and heterodimeric forms of certain C-terminal fragments of adiponectin receptor. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, inhibiting a protease, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed.
摘要（中）：

公开了用于确定条件进展，条件开始或治疗以患者脂肪细胞不平衡为特征的病症的功效的方法。 此外，公开了使用脂联素受体的某些C末端片段的单体，同二聚体和异二聚体形式治疗糖尿病，异常脂肪细胞活性和胰岛素抵抗的方法。 此外，治疗异常脂肪细胞活性，治疗代谢综合征，引起胰岛素分泌，增加胰岛素水平，抑制胰岛素降解酶，治疗阿尔茨海默病，治疗与脂联素水平相关的心血管疾病，抑制ADAM-17酶，抑制蛋白酶，治疗 公开了与TNF-α相关的病症和治疗与HER2-neu相关的病症。 还公开了组合物，剂型和试剂盒。

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