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    ADIPONECTIN RECEPTOR FRAGMENTS AND METHODS OF USE
    1.
    发明申请
    ADIPONECTIN RECEPTOR FRAGMENTS AND METHODS OF USE 有权
    ADIPONECTIN受体片段和使用方法

    公开(公告)号：US20090143275A1

    公开(公告)日：2009-06-04

    申请号：US12169983

    申请日：2008-07-09

    申请人： Michael J. Pugia ,  Rui Ma

    发明人： Michael J. Pugia ,  Rui Ma

    IPC分类号： A61K38/02 ,  A61P3/10 ,  A61P35/00

    CPC分类号： C07K14/72 ,  A61K38/00

    摘要： Methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using C-terminal fragments of adiponectin receptor R1. Methods of causing the secretion of insulin in healthy and diabetic patients using C-terminal fragments of adiponectin receptor R1 are also disclosed. In addition, methods are disclosed of increasing the insulin levels in healthy patients using C-terminal fragments of adiponectin receptor R1. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed.

    摘要翻译： 公开了使用脂联素受体R1的C末端片段治疗糖尿病，异常脂肪细胞活性和胰岛素抵抗的方法。 还公开了使用脂联素受体R1的C末端片段在健康和糖尿病患者中分泌胰岛素的方法。 此外，公开了使用脂联素受体R1的C末端片段增加健康患者的胰岛素水平的方法。 另外，处理异常脂肪细胞活性，治疗代谢综合征，引起胰岛素分泌，增加胰岛素水平，抑制胰岛素降解酶，治疗阿尔茨海默氏病，治疗与脂联素水平相关的心血管疾病，抑制ADAM-17酶，治疗与 公开了TNF-α和治疗与HER2-neu相关的病症。 还公开了组合物，剂型和试剂盒。

    Monomeric and dimeric forms of adiponectin receptor fragments and methods of use
    2.
    发明授权
    Monomeric and dimeric forms of adiponectin receptor fragments and methods of use 有权
    脂联素受体片段的单体和二聚体形式和使用方法

    公开(公告)号：US08865648B2

    公开(公告)日：2014-10-21

    申请号：US13265968

    申请日：2010-04-13

    申请人： Michael J. Pugia ,  Rui Ma

    发明人： Michael J. Pugia ,  Rui Ma

    IPC分类号： A61K38/00 ,  A61K38/26 ,  A61K38/22 ,  C07K14/605 ,  A61K38/28 ,  C07K14/575 ,  C07K7/06 ,  C07K7/02 ,  C07K7/64 ,  C07K11/00 ,  C07K14/47 ,  C07K14/785 ,  A61K39/00 ,  C07K14/005 ,  G01N33/574

    CPC分类号： C07K14/705 ,  G01N33/574 ,  G01N33/57415 ,  G01N33/6872 ,  G01N2333/575 ,  G01N2800/2821 ,  G01N2800/52 ,  G01N2800/56

    摘要： Methods are disclosed for determining progression of a condition, onset of a condition, or efficacy of treatment of a condition characterized by an adipocyte imbalance in a patient. In addition, methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using monomeric, homodimeric, and heterodimeric forms of certain C-terminal fragments of adiponectin receptor. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, inhibiting a protease, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed.

    摘要翻译： 公开了用于确定条件进展，条件开始或治疗以患者脂肪细胞不平衡为特征的病症的功效的方法。 此外，公开了使用脂联素受体的某些C末端片段的单体，同二聚体和异二聚体形式治疗糖尿病，异常脂肪细胞活性和胰岛素抵抗的方法。 此外，治疗异常脂肪细胞活性，治疗代谢综合征，引起胰岛素分泌，增加胰岛素水平，抑制胰岛素降解酶，治疗阿尔茨海默病，治疗与脂联素水平相关的心血管疾病，抑制ADAM-17酶，抑制蛋白酶，治疗 公开了与TNF-α相关的病症和治疗与HER2-neu相关的病症。 还公开了组合物，剂型和试剂盒。

    ADIPONECTIN RECEPTOR FRAGMENTS AND METHODS OF USE
    4.
    发明申请
    ADIPONECTIN RECEPTOR FRAGMENTS AND METHODS OF USE 有权
    ADIPONECTIN受体片段和使用方法

    公开(公告)号：US20110301089A1

    公开(公告)日：2011-12-08

    申请号：US13211558

    申请日：2011-08-17

    申请人： Michael J. Pugia ,  Rui Ma

    发明人： Michael J. Pugia ,  Rui Ma

    IPC分类号： A61K38/17 ,  A61P9/00

    CPC分类号： C07K14/72 ,  A61K38/00

    摘要： Methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using C-terminal fragments of adiponectin receptor R1. Methods of causing the secretion of insulin in healthy and diabetic patients using C-terminal fragments of adiponectin receptor R1 are also disclosed. In addition, methods are disclosed of increasing the insulin levels in healthy patients using C-terminal fragments of adiponectin receptor R1. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed.

    摘要翻译： 公开了使用脂联素受体R1的C末端片段治疗糖尿病，异常脂肪细胞活性和胰岛素抵抗的方法。 还公开了使用脂联素受体R1的C末端片段在健康和糖尿病患者中分泌胰岛素的方法。 此外，公开了使用脂联素受体R1的C末端片段增加健康患者的胰岛素水平的方法。 另外，处理异常脂肪细胞活性，治疗代谢综合征，引起胰岛素分泌，增加胰岛素水平，抑制胰岛素降解酶，治疗阿尔茨海默氏病，治疗与脂联素水平相关的心血管疾病，抑制ADAM-17酶，治疗与 公开了TNF-α和治疗与HER2-neu相关的病症。 还公开了组合物，剂型和试剂盒。

    Adiponectin receptor fragments and methods of use
    5.
    发明授权
    Adiponectin receptor fragments and methods of use 有权
    脂联素受体片段和使用方法

    公开(公告)号：US08017573B2

    公开(公告)日：2011-09-13

    申请号：US12169983

    申请日：2008-07-09

    申请人： Michael J. Pugia ,  Rui Ma

    发明人： Michael J. Pugia ,  Rui Ma

    IPC分类号： A61K38/17

    CPC分类号： C07K14/72 ,  A61K38/00

    摘要： Methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using C-terminal fragments of adiponectin receptor R1. Methods of causing the secretion of insulin in healthy and diabetic patients using C-terminal fragments of adiponectin receptor R1 are also disclosed. In addition, methods are disclosed of increasing the insulin levels in healthy patients using C-terminal fragments of adiponectin receptor R1. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed.

    摘要翻译： 公开了使用脂联素受体R1的C末端片段治疗糖尿病，异常脂肪细胞活性和胰岛素抵抗的方法。 还公开了使用脂联素受体R1的C末端片段在健康和糖尿病患者中分泌胰岛素的方法。 此外，公开了使用脂联素受体R1的C末端片段增加健康患者的胰岛素水平的方法。 另外，处理异常脂肪细胞活性，治疗代谢综合征，引起胰岛素分泌，增加胰岛素水平，抑制胰岛素降解酶，治疗阿尔茨海默氏病，治疗与脂联素水平相关的心血管疾病，抑制ADAM-17酶，治疗与 公开了TNF-α和治疗与HER2-neu相关的病症。 还公开了组合物，剂型和试剂盒。

    DRIVING CIRCUIT, SHIFTING REGISTER, GATE DRIVER, ARRAY SUBSTRATE AND DISPLAY DEVICE
    7.
    发明申请
    DRIVING CIRCUIT, SHIFTING REGISTER, GATE DRIVER, ARRAY SUBSTRATE AND DISPLAY DEVICE 审中-公开
    驱动电路，移位寄存器，门驱动器，阵列基板和显示器件

    公开(公告)号：US20140086379A1

    公开(公告)日：2014-03-27

    申请号：US13805886

    申请日：2012-11-09

    申请人： Rui Ma ,  Xianjie Shao ,  Guolei Wang ,  Ming Hu ,  Byung Cheon Lim ,  Zhizhong Tu

    发明人： Rui Ma ,  Xianjie Shao ,  Guolei Wang ,  Ming Hu ,  Byung Cheon Lim ,  Zhizhong Tu

    IPC分类号： G11C19/28 ,  H03K5/00

    CPC分类号： G11C19/28 ,  H03K5/00

    摘要： The disclosure relates to the field of liquid crystal display, and provides a driving circuit, a shifting register, a gate driver, an array substrate and a display device. The driving circuit comprises a pull-up module, a first pull-down module, a second pull-down module, a pull-up driving module, a pull-down driving module and a resetting module, wherein the first pull-down module outputs a switching-off signal to the output terminal according to a signal input from the clock retarding signal input terminal and a signal at a pull-down node; a second pull-down module, when the signal input from the signal input terminal is at a low level, outputs a switching-off signal to the pull-up node and the output terminal according to a signal input from a clock signal input terminal; wherein when the signal input from the signal input terminal is at a high level, the signal input from the clock retarding signal input terminal is also at a high level, and the signal input from the clock signal input terminal and that input from the clock retarding signal input terminal are opposite in phase. The driving circuit according to the disclosure can effectively remove the defect of the threshold voltage drifting due to the gate being applied to a bias voltage stress, and can also decrease the noise of the output voltage.

    摘要翻译： 本公开涉及液晶显示领域，并提供驱动电路，移位寄存器，栅极驱动器，阵列基板和显示装置。 驱动电路包括上拉模块，第一下拉模块，第二下拉模块，上拉驱动模块，下拉驱动模块和复位模块，其中第一下拉模块输出 根据从时钟延迟信号输入端子输入的信号和在下拉节点处的信号将输出端子切断信号; 第二下拉模块，当从所述信号输入端子输入的信号处于低电平时，根据从时钟信号输入端子输入的信号，向所述上拉节点和所述输出端子输出关断信号; 其中，当从信号输入端输入的信号处于高电平时，从时钟延迟信号输入端输入的信号也处于高电平，从时钟信号输入端输入的信号和从时钟延迟信号输入的信号 信号输入端子相位相反。 根据本公开的驱动电路可以有效地消除由于栅极被施加到偏置电压应力而导致的阈值电压漂移的缺陷，并且还可以降低输出电压的噪声。

    Method and terminal for selecting random access resource
    8.
    发明授权
    Method and terminal for selecting random access resource 有权
    选择随机存取资源的方法和终端

    公开(公告)号：US08570902B2

    公开(公告)日：2013-10-29

    申请号：US13203446

    申请日：2009-09-25

    申请人： Zhongda Du ,  Rui Ma ,  Bin Yu

    发明人： Zhongda Du ,  Rui Ma ,  Bin Yu

    IPC分类号： H04L12/28

    CPC分类号： H04W74/008 ,  H04W36/0077 ,  H04W74/0833

    摘要： The present invention discloses a method and terminal for selecting a random access resource, the method includes: the terminal receives the physical downlink control channel signaling sent by a system; the terminal determines the first subframe which meets a condition A and contains a random access resource from the subsequent subframes of the subframe receiving the physical downlink control channel signaling, the condition A is that the time difference between the first subframe and the subframe receiving the physical downlink control channel signaling is greater than or equal to k, k is the time delay defined by the physical layer of the terminal; and the terminal starts a selection on the subframe containing a random access source from the first subframe.

    摘要翻译： 本发明公开了一种选择随机接入资源的方法和终端，该方法包括：终端接收系统发送的物理下行控制信道信令; 终端确定满足条件A的第一子帧，并且从接收物理下行链路控制信道信令的子帧的后续子帧中包含随机接入资源，条件A是第一子帧与接收物理的子帧之间的时间差 下行控制信道信令大于或等于k，k是由终端的物理层定义的时延; 并且终端从包含来自第一子帧的随机接入源的子帧开始选择。

    Method And System For Mobility Management Of A Terminal On A Radio Relay System
    10.
    发明申请
    Method And System For Mobility Management Of A Terminal On A Radio Relay System 审中-公开
    无线电中继系统终端的移动性管理方法与系统

    公开(公告)号：US20120113887A1

    公开(公告)日：2012-05-10

    申请号：US13258388

    申请日：2009-12-21

    申请人： Xiaoqin Shen ,  Lifeng Han ,  Rui Ma

    发明人： Xiaoqin Shen ,  Lifeng Han ,  Rui Ma

    IPC分类号： H04W36/32 ,  H04W88/04

    CPC分类号： H04W36/0033 ,  H04B7/2606 ,  H04W84/047 ,  H04W92/20

    摘要： A method and system for mobility management of a User Equipment (UE) in a radio relay system is used for resolving the technical problem of performing a UE handover between different relay stations belonging to a same Donor eNodeB (DeNB). The method comprises that: an X2 interface link is established between the relay stations belonging to one DeNB; a source relay station transmits a handover request to a target relay station, and the target relay station performs admission control; when the target relay station permits the UE to access, the source relay station performs forwarding of UE context and cached data; after the UE has successfully accessed the target relay station, the target relay station notifies the DeNB that the path has changed, and the DeNB performs a path handover. In the handover flow of the disclosure, only some control for forwarding data is needed between the source relay station and the target relay station, the forwarding through the DeNB and the processing with a Mobility Management Unit (MME) or a Serving GateWay (GW) are not needed, therefore the handover flow is simplified, and handover delay is decreased to a certain extent.

    摘要翻译： 用于无线电中继系统中的用户设备（UE）的移动性管理的方法和系统用于解决在属于同一个供体eNodeB（DeNB）的不同中继站之间进行UE切换的技术问题。 该方法包括：在属于一个DeNB的中继站之间建立X2接口链路; 源中继站向目标中继站发送切换请求，目标中继站进行准入控制; 当目标中继站允许UE接入时，源中继站执行UE上下文和缓存数据的转发; 在UE成功访问目标中继站之后，目标中继站通知DeNB路径已经改变，并且DeNB执行路径切换。 在本公开的切换流程中，在源中继站和目标中继站之间仅需要转发数据的一些控制，通过DeNB的转发以及移动性管理单元（MME）或服务网关（GW）的处理， 因此切换流程被简化，切换延迟降低到一定程度。