发明授权
- 专利标题： Methods and compositions for inhibition of the transitional endoplasmic reticulum ATPase
- 专利标题（中）： 抑制过渡性内质网ATP酶的方法和组合物
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申请号： US13103003申请日： 2011-05-06
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公开(公告)号： US08865708B2公开(公告)日： 2014-10-21
- 发明人: Raymond J. Deshaies , Tsui-Fen Chou , Frank J. Schoenen , Kelin Li , Kevin J. Frankowski , Jeffrey Aube , Samuel W. Gerritz , Han-Jie Zhou
- 申请人： Raymond J. Deshaies , Tsui-Fen Chou , Frank J. Schoenen , Kelin Li , Kevin J. Frankowski , Jeffrey Aube , Samuel W. Gerritz , Han-Jie Zhou
- 申请人地址： US CA Pasadena US KS Lawrence US CA Burlingame
- 专利权人： California Institute of Technology,The University of Kansas,Cleave Biosciences, Inc.
- 当前专利权人： California Institute of Technology,The University of Kansas,Cleave Biosciences, Inc.
- 当前专利权人地址： US CA Pasadena US KS Lawrence US CA Burlingame
- 代理机构： Schwegman Lundberg & Woessner, P.A.
- 主分类号： A61K31/54
- IPC分类号： A61K31/54 ; A61K31/535 ; A61K31/538 ; A61K31/517 ; A61K31/4184 ; C12Q1/42 ; A61K31/53 ; C12Q1/48
摘要：
Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof.