发明授权
- 专利标题: Immunoglobulins insertions, deletions, and substitutions
- 专利标题(中): 免疫球蛋白插入,缺失和置换
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申请号: US13846527申请日: 2013-03-18
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公开(公告)号: US08883147B2公开(公告)日: 2014-11-11
- 发明人: Gregory Lazar , Bassil Dahiyat , Wei Dang , Sher Bahadur Karki , Omid Vafa
- 申请人: Gregory Lazar , Bassil Dahiyat , Wei Dang , Sher Bahadur Karki , Omid Vafa
- 申请人地址: US CA Monrovia
- 专利权人: Xencor, Inc.
- 当前专利权人: Xencor, Inc.
- 当前专利权人地址: US CA Monrovia
- 代理机构: Morgan, Lewis & Bockius, LLP
- 代理商 Robin M. Silva; Christina A. MacDougall
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; A61K39/40 ; C07K16/32 ; C07K16/28 ; C07K16/00
摘要:
An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more FcγRs, wherein said Fc variant comprises at least one amino acid insertion in the Fc region of said parent Fc polypeptide.
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