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发明授权
US08895709B2 Isolation and purification of antibodies using protein A affinity chromatography 有权
使用蛋白A亲和层析分离和纯化抗体

Isolation and purification of antibodies using protein A affinity chromatography
摘要：
Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
摘要（中）：

本文公开了用于分离和纯化抗体的方法，其中使用亲和层析步骤导致针对药物用途足够纯的抗体组合物。 本文描述的方法包括pH病毒还原/失活，超滤/渗滤，亲和层析，优选蛋白A亲和力，离子交换层析和疏水层析。 此外，本发明涉及包含本发明的一种或多种抗体的药物组合物。

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