发明授权
US08895755B2 Intermediates for preparing dual-acting benzyl triazole antihypertensive agents having angiotensin II type I receptor antagonist activity and neprilysin-inhibition activity
有权
用于制备具有血管紧张素II I型受体拮抗剂活性和去甲肾上腺素抑制活性的双作用苄基三唑抗高血压药的中间体
- 专利标题： Intermediates for preparing dual-acting benzyl triazole antihypertensive agents having angiotensin II type I receptor antagonist activity and neprilysin-inhibition activity
- 专利标题（中）： 用于制备具有血管紧张素II I型受体拮抗剂活性和去甲肾上腺素抑制活性的双作用苄基三唑抗高血压药的中间体
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申请号： US14035042申请日： 2013-09-24
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公开(公告)号： US08895755B2公开(公告)日： 2014-11-25
- 发明人: Paul Allegretti , Seok-Ki Choi , Roland Gendron , Paul R. Fatheree , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- 申请人： Paul Allegretti , Seok-Ki Choi , Roland Gendron , Paul R. Fatheree , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- 申请人地址： US CA South San Francisco
- 专利权人： Theravance Biopharma R&D IP, LLC
- 当前专利权人： Theravance Biopharma R&D IP, LLC
- 当前专利权人地址： US CA South San Francisco
- 代理商 Jeffrey A. Hagenah; Shelley Eberle
- 主分类号： C07D249/08
- IPC分类号： C07D249/08 ; C07D513/04 ; C07D213/89 ; C07D233/64 ; C07D233/70 ; A61K31/4188 ; C07D233/68 ; C07D513/14 ; C07D231/14 ; C07D233/90 ; A61K31/4196 ; C07D403/10 ; C07D401/12 ; C07D213/64 ; C07D207/46 ; A61K45/00 ; C07D255/02 ; A61K31/415 ; A61K31/4412 ; A61K31/417
摘要：
The invention is directed to intermediates for preparing compounds having the formula: wherein: Ar, X, R3 ,and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity.
公开/授权文献
- US20140024835A1 DUAL-ACTING ANTIHYPERTENSIVE AGENTS 公开/授权日：2014-01-23
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