发明授权
US08901123B2 Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-B][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
有权
2-氟-N-甲基-4- [7-（喹啉-6-基 - 甲基） - 咪唑并[1,2-B] [1,2,4]三嗪-2-基]苯甲酰胺的盐和相关的方法 准备相同
![Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-B][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same](/docs/US/2014-12-02/US08901123B2/abs.jpg.600x600.jpg)
- 专利标题： Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-B][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
- 专利标题（中）： 2-氟-N-甲基-4- [7-（喹啉-6-基 - 甲基） - 咪唑并[1,2-B] [1,2,4]三嗪-2-基]苯甲酰胺的盐和相关的方法 准备相同
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申请号： US13793864申请日： 2013-03-11
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公开(公告)号： US08901123B2公开(公告)日： 2014-12-02
- 发明人: Lingkai Weng , Lei Qiao , Jiacheng Zhou , Pingli Liu , Yongchun Pan
- 申请人： Lingkai Weng , Lei Qiao , Jiacheng Zhou , Pingli Liu , Yongchun Pan
- 申请人地址： US DE Wilmington
- 专利权人： Incyte Corporation
- 当前专利权人： Incyte Corporation
- 当前专利权人地址： US DE Wilmington
- 代理机构： Lathrop & Gage LLP
- 代理商 Brian C. Trinque
- 主分类号： A01N43/64
- IPC分类号： A01N43/64 ; A61K31/53 ; C07D487/00
![Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-B][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same](/abs-image/US/2014/12/02/US08901123B2/abs.jpg.150x150.jpg)
摘要：
The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.
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