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![Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same](/abs-image/US/2013/04/16/US08420645B2/abs.jpg.150x150.jpg)
1.发明授权Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same 有权2-氟-N-甲基-4- [7-（喹啉-6-基 - 甲基） - 咪唑并[1,2-b] [1,2,4]三嗪-2-基]苯甲酰胺的盐和相关的方法 准备相同公开(公告)号：US08420645B2
公开(公告)日：2013-04-16
申请号：US12469360
申请日：2009-05-20
申请人： Lingkai Weng , Lei Qiao , Jiacheng Zhou , Pingli Liu , Yongchun Pan
发明人： Lingkai Weng , Lei Qiao , Jiacheng Zhou , Pingli Liu , Yongchun Pan
IPC分类号： A01N43/64 , A61K31/53 , C07D251/00
CPC分类号： A61K31/53 , C07D253/07 , C07D401/10 , C07D487/04
摘要： The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.
摘要翻译： 本发明涉及c-Met激酶抑制剂2-氟-N-甲基-4- [7-（喹啉-6-基甲基） - 咪唑并[1,2-b] [1]的二氯氯酸和二苯磺酸盐 ，2,4]三嗪-2-基]苯甲酰胺及其药物组合物，其可用于治疗与激酶途径失调相关的癌症和其它疾病。 本发明还涉及制备2-氟-N-甲基-4- [7-（喹啉-6-基甲基）咪唑并[1,2-b] [1,2,4]三嗪-2-酮的方法和中间体， 吡啶-2-基]苯甲酰胺及其盐。
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![Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-B][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same](/abs-image/US/2014/12/02/US08901123B2/abs.jpg.150x150.jpg)
2.发明授权Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-B][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same 有权2-氟-N-甲基-4- [7-（喹啉-6-基 - 甲基） - 咪唑并[1,2-B] [1,2,4]三嗪-2-基]苯甲酰胺的盐和相关的方法 准备相同公开(公告)号：US08901123B2
公开(公告)日：2014-12-02
申请号：US13793864
申请日：2013-03-11
申请人： Lingkai Weng , Lei Qiao , Jiacheng Zhou , Pingli Liu , Yongchun Pan
发明人： Lingkai Weng , Lei Qiao , Jiacheng Zhou , Pingli Liu , Yongchun Pan
IPC分类号： A01N43/64 , A61K31/53 , C07D487/00
CPC分类号： A61K31/53 , C07D253/07 , C07D401/10 , C07D487/04
摘要： The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.
摘要翻译： 本发明涉及c-Met激酶抑制剂2-氟-N-甲基-4- [7-（喹啉-6-基甲基） - 咪唑并[1,2-b] [1]的二氯氯酸和二苯磺酸盐 ，2,4]三嗪-2-基]苯甲酰胺及其药物组合物，其可用于治疗与激酶途径失调相关的癌症和其它疾病。 本发明还涉及制备2-氟-N-甲基-4- [7-（喹啉-6-基甲基）咪唑并[1,2-b] [1,2,4]三嗪-2-酮的方法和中间体， 吡啶-2-基]苯甲酰胺及其盐。
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![SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)-IMIDAZO[1,2-b][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME](/abs-image/US/2009/11/26/US20090291956A1/abs.jpg.150x150.jpg)
3.发明申请SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)-IMIDAZO[1,2-b][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME 有权2-氟-N-甲基-4- [7-（喹啉-6-基甲基） - 咪唑并[1,2-b] [1,2,4]三嗪-2-基]苯甲酰胺及其制备方法的相关 准备相同公开(公告)号：US20090291956A1
公开(公告)日：2009-11-26
申请号：US12469360
申请日：2009-05-20
申请人： Lingkai Weng , Lei Qiao , Jiacheng Zhou , Pingli Liu , Yongchun Pan
发明人： Lingkai Weng , Lei Qiao , Jiacheng Zhou , Pingli Liu , Yongchun Pan
IPC分类号： A61K31/53 , C07D487/04 , C12N9/99 , C12N5/06 , A61P35/00 , C07D401/06 , C07D215/14 , C07D253/07
CPC分类号： A61K31/53 , C07D253/07 , C07D401/10 , C07D487/04
摘要： The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.
摘要翻译： 本发明涉及c-Met激酶抑制剂2-氟-N-甲基-4- [7-（喹啉-6-基甲基） - 咪唑并[1,2-b] [1]的二氯氯酸和二苯磺酸盐 ，2,4]三嗪-2-基]苯甲酰胺及其药物组合物，其可用于治疗与激酶途径失调相关的癌症和其它疾病。 本发明还涉及制备2-氟-N-甲基-4- [7-（喹啉-6-基甲基）咪唑并[1,2-b] [1,2,4]三嗪-2-酮的方法和中间体， 吡啶-2-基]苯甲酰胺及其盐。
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4.发明申请公开(公告)号：US20120058079A1
公开(公告)日：2012-03-08
申请号：US13294711
申请日：2011-11-11
申请人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
发明人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
IPC分类号： A61K31/4245 , A61P31/12 , A61P37/04 , A61P27/12 , A61P37/06 , C07D271/08 , A61K39/00 , A61K39/12 , A61K38/20 , A61K39/395 , C12N9/99 , A61P35/00 , A61P25/24
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
摘要： The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
摘要翻译： 本发明涉及1,2,5-恶二唑衍生物及其组合物，其为吲哚胺2,3-双加氧酶的抑制剂，可用于治疗癌症和其它疾病，以及其用于治疗癌症和其它疾病的方法和中间体 制备这样的1,2,5-恶二唑衍生物。
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公开(公告)号：US08796319B2
公开(公告)日：2014-08-05
申请号：US13294711
申请日：2011-11-11
申请人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
发明人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
IPC分类号： A61K31/4245 , C07D413/12 , C07D271/08
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
摘要： The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
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6.发明申请公开(公告)号：US20140023663A1
公开(公告)日：2014-01-23
申请号：US14033117
申请日：2013-09-20
申请人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
发明人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
IPC分类号： C07D271/08 , C07D413/12 , A61K39/395 , A61K31/4245
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
摘要： The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
摘要翻译： 本发明涉及1,2,5-恶二唑衍生物及其组合物，其为吲哚胺2,3-双加氧酶的抑制剂，可用于治疗癌症和其它疾病，以及其用于治疗癌症和其它疾病的方法和中间体 制备这样的1,2,5-恶二唑衍生物。
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7.发明申请公开(公告)号：US20100015178A1
公开(公告)日：2010-01-21
申请号：US12498782
申请日：2009-07-07
申请人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
发明人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
IPC分类号： A61K39/12 , C07D271/08 , A61K31/4245 , C12N9/99 , A61P37/06 , A61P35/00 , A61P31/12 , A61P25/00 , A61P25/24 , A61P27/12 , A61K39/00
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
摘要： The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
摘要翻译： 本发明涉及1,2,5-恶二唑衍生物及其组合物，其为吲哚胺2,3-双加氧酶的抑制剂，可用于治疗癌症和其它疾病，以及其用于治疗癌症和其它疾病的方法和中间体 制备这样的1,2,5-恶二唑衍生物。
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公开(公告)号：US08410265B2
公开(公告)日：2013-04-02
申请号：US12687623
申请日：2010-01-14
申请人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , Brian W. Metcalf , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , James D. Rodgers , Haisheng Wang
发明人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , Brian W. Metcalf , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , James D. Rodgers , Haisheng Wang
IPC分类号： C07D487/00
CPC分类号： C07D487/04 , C07F5/025 , C07F7/083 , C07F7/10 , C07F7/1892 , Y02P20/55
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
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9.发明申请公开(公告)号：US20100190981A1
公开(公告)日：2010-07-29
申请号：US12687623
申请日：2010-01-14
申请人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , Brian W. Metcalf , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , James D. Rodgers , Haisheng Wang
发明人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , Brian W. Metcalf , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , James D. Rodgers , Haisheng Wang
IPC分类号： C07D487/04 , C07D231/16 , C07F5/02
CPC分类号： C07D487/04 , C07F5/025 , C07F7/083 , C07F7/10 , C07F7/1892 , Y02P20/55
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
摘要翻译： 本发明涉及制备式III的手性取代吡唑并吡咯并[2,3-d]嘧啶的方法和相关的合成中间体化合物。 手性取代的吡唑基吡咯并[2,3-d]嘧啶可用作Janus Kinase家族蛋白酪氨酸激酶（JAKs）的抑制剂，用于治疗炎性疾病，骨髓增生性疾病和其他疾病。
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10.发明授权公开(公告)号：US09000161B2
公开(公告)日：2015-04-07
申请号：US13761742
申请日：2013-02-07
申请人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , Brian W. Metcalf
发明人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , Brian W. Metcalf
IPC分类号： C07D487/00 , C07D487/04 , C07F7/18 , C07F7/10
CPC分类号： C07D487/04 , C07F5/025 , C07F7/083 , C07F7/10 , C07F7/1892 , Y02P20/55
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
摘要翻译： 本发明涉及制备式III的手性取代吡唑并吡咯并[2,3-d]嘧啶的方法和相关的合成中间体化合物。 手性取代的吡唑基吡咯并[2,3-d]嘧啶可用作Janus Kinase家族蛋白酪氨酸激酶（JAKs）的抑制剂，用于治疗炎性疾病，骨髓增生性疾病和其他疾病。
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