发明授权
US08907069B2 Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent
有权
缀合于治疗或诊断剂的双特异性抗体和地高辛的复合物
- 专利标题： Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent
- 专利标题（中）： 缀合于治疗或诊断剂的双特异性抗体和地高辛的复合物
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申请号： US13382502申请日： 2010-07-05
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公开(公告)号： US08907069B2公开(公告)日： 2014-12-09
- 发明人: Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Guy Georges , Alexander Haas , Eike Hoffmann , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
- 申请人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Guy Georges , Alexander Haas , Eike Hoffmann , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
- 申请人地址： US NJ Little Falls
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Little Falls
- 代理商 Janet M. Martineau
- 优先权： EP09164612 20090706
- 国际申请： PCT/EP2010/004051 WO 20100705
- 国际公布： WO2011/003557 WO 20110113
- 主分类号： C07K16/46
- IPC分类号： C07K16/46 ; A61K51/10 ; A61K49/00 ; A61K47/48 ; C07K16/28 ; B82Y5/00 ; C12N15/113 ; A61K39/395 ; C07K16/16 ; C07K16/44 ; C07K16/32 ; C12N15/11 ; A61K31/704 ; A61K39/00
摘要：
The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
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